Are monocytes progenitor cells?
In the post-natal bone marrow, monocytes are produced by HSCs via progenitors with progressively restricted lineage potential that ultimately commit to monocyte production.
What is the difference between monocytes and dendritic cells?
Monocytes are able to differentiate to dendritic cells (DCs) under inflammatory situations. Different monocyte subsets show distinct inflammatory cytokine profiles and differentiation potential under steady-state and inflammatory situations.
Do dendritic cells come from monocytes?
Monocyte-derived Dendritic cells (Mo-DC) are a distinct DC subset, involved in inflammation and infection, they originate from monocytes upon stimulation in the circulation and their activation and function may vary in autoimmune diseases.
What is the progenitor cell of macrophages?
Macrophage/Dendritic cell progenitor cells (MDPs) are a subset of proliferating cells in the bone marrow that share phenotypic characteristics with myeloid precursor populations. They give rise to dendritic cells (DC) subsets, and typically can not differentiate into granulocytes.
What are monocytes macrophages and dendritic cells?
Monocytes and macrophages are critical effectors and regulators of inflammation and the innate immune response, the immediate arm of the immune system. Dendritic cells initiate and regulate the highly pathogen-specific adaptive immune responses and are central to the development of immunologic memory and tolerance.
What is the origin of dendritic cells?
Dendritic cells (DCs) are uniquely potent in orchestrating T cell immune response, thus they are indispensable immune sentinels. They originate from progenitors in the bone marrow through hematopoiesis, a highly regulated developmental process involving multiple cellular and molecular events.
What is progenitor cell?
Often confused with adult stem cells, progenitor cells are early descendants of stem cells that can differentiate to form one or more kinds of cells, but cannot divide and reproduce indefinitely. A progenitor cell. is often more limited than a stem cell in the kinds of cells it can become.
What are the examples of progenitor cells?
Multipotent progenitor cells are those with the potential to differentiate into a subset of cell types….Myeloid progenitor cells are precursors to the following types of blood cells:
- Red blood cells/erythrocytes.
- Platelets.
- Mast cells.
- Osteoclasts.
- Granulocytes.
- Monocyte-macrophages.
- Dendritic cells.
Who discovered dendritic cells?
Ralph Steinman
We referred to them as A cells or the third cell type. In 1973, Ralph Steinman and Zanvil Cohn described a rare cell type in murine spleen cells which was phagocytic but had dendrite like protrusions; they named them dendritic cells (DCs). In 1978, Steinman reported that DC were required for mixed lymphocyte reactions.
Are macrophage/dendritic progenitors committed to the DC lineage?
In mice, two restricted dendritic cell (DC) progenitors, macrophage/dendritic progenitors (MDPs) and common dendritic progenitors (CDPs), demonstrate increasing commitment to the DC lineage, as they sequentially lose granulocyte and monocyte potential, respectively.
What are dendritic progenitors (DCS) and monocytes in mice?
In mice, DCs and monocytes arise from a macrophage/dendritic progenitor (MDP; Fogg et al., 2006 ), which produces monocytes, and a common dendritic progenitor (CDP) that is restricted to the DC fate ( Shortman and Naik, 2007; Liu et al., 2009; Geissmann et al., 2010; Merad et al., 2013 ).
What are the divergent features of monocyte-derived populations?
Such divergent features of the monocyte-derived populations highlight the impact of the local tissue microenvironment on the differentiation of monocytes and particularly on their function. 3.3. Ontogeny of human DC and monocytes
Is there any government funding for the development of monocytes?
Work by FG and KL on the development of monocytes, macrophages and dendritic cells is funded by MRC G0900867 to FG, and NIH R01 HL058108 to K.L. References and Notes 1. van Furth R, Cohn ZA.