What molecular subtypes of breast cancer is most common?
Luminal A (58.5%) subtype was the most prevalent, followed by triple negative (16%), luminal B (14%), and HER2-positive (11.5%). The average age of the patient at the time of diagnosis was found to be 49 years with an average tumor size of 3.2 cm.
How many molecular subtypes of breast cancer are there?
Breast cancer has four primary molecular subtypes, defined in large part by hormone receptors (HR) and other types of proteins involved (or not involved) in each cancer: Luminal A or HR+/HER2- (HR-positive/HER2-negative) Luminal B or HR+/HER2+ (HR-positive/HER2-positive)
What are the main subtypes of breast cancer?
Subtypes include tubular, mucinous, medullary and papillary. Your subtype gives your doctor some clues about your prognosis and how your cells may respond to treatment. The degree of difference between the cancer cells and normal cells.
What are the molecular classes of breast cancer?
The current molecular classification divides breast cancer into five groups as luminal A, luminal B, HER-2, basal and normal breast like. Further grouping of these subgroups seem possible and necessary.
Can luminal A be Grade 3?
Grade 3 tumors were detected in 18.0% of luminal A tumors, 58.9% of luminal B (HER2-), 75.4% of luminal B (HER2+), 92.7% of HER2, and 85.1% of basal-like tumors.
What are molecular subtypes in cancer?
Molecular subtyping of cancer, as its name suggests, is a new way to classify cancers into different groups based on molecular data and classification models. Contrary to the traditional histological classification of cancer, molecular classifications rely on biomarkers and classifiers.
What are molecular subtypes?
Molecular subtyping refers to the use of -omics data to find clusters of tumors within a cancer type that have shared characteristics.
What is luminal A subtype?
Luminal-A subtype is defined as ER-positive and/or PR-positive tumors with negative HER2 and low Ki67 (proliferating cell nuclear antigen) index by immunohistochemistry[14]. Patients with luminal-A breast cancer have a good prognosis; the relapse rate is significantly lower than the other subtypes.
What is Group 1 luminal A?
Luminal A breast cancer is hormone-receptor positive (estrogen-receptor and/or progesterone-receptor positive), HER2 negative, and has low levels of the protein Ki-67, which helps control how fast cancer cells grow. Luminal A cancers are low-grade, tend to grow slowly and have the best prognosis.
What is Ki-67 a marker for?
The expression of Ki67 is strongly associated with tumor cell proliferation and growth, and is widely used in routine pathological investigation as a proliferation marker. The nuclear protein Ki67 (pKi67) is an established prognostic and predictive indicator for the assessment of biopsies from patients with cancer.