What is zieve syndrome?

Zieve’s syndrome (ZS) is a triad of jaundice, hemolytic anemia, and hyperlipidemia that develops secondary to alcohol-induced liver injury [1]. It was first described by Dr. Leslie Zieve in 1957. Patients with ZS present with abdominal pain, nausea, and other nonspecific symptoms [1].

What causes alcohol liver disease?

Alcoholic liver disease is caused by heavy use of alcohol. The liver breaks down alcohol. If you drink more than it can process, it can become seriously damaged. The effects of alcohol on the liver depend on how much and how long you have been drinking.

What causes Maha?

Possible causes of MAHA include mechanical heart valve, malignant hypertension, vasculitis, adenocarcinoma, preeclampsia/eclampsia, disseminated intravascular coagulation (DIC), thrombotic thrombocytopenic purpura (TTP), and hemolytic-uremic syndrome (HUS)/atypical HUS (see Chapter 20, Disorders of Hemostasis and …

Can fatty liver cause hemolytic anemia?

Jaundice, hyperlipidemia and hemolytic anemia: a heretofore unrecognized syndrome associated with alcoholic fatty liver and cirrhosis.

What alcohol is hardest on the liver?

“Hard liquor contains more alcohol than beer or wine, making it more dangerous for your liver,” continues Coleman. “A single shot of 80-proof hard liquor contains about 15 grams of alcohol and most shots contain even more alcohol than this.” Another alcoholic beverage also takes a considerable toll on your liver.

What is the final stage of liver damage from drinking?

Cirrhosis is the final stage of alcohol-related liver disease. It usually happens after many years of heavy drinking.

How is MAHA diagnosed?

Pathognomonic Findings in MAHA:

Clinicopathologic features of hemolysis (as described in Clinical Features section)
A negative Coombs test (also called a direct antiglobulin test)
Schistocytes on microscopic examination of the peripheral blood smear (usually more than two per high power field [100x])
Thrombocytopenia.