What CATIE found results from the schizophrenia trial?
The most striking result of the CATIE study, which enrolled almost 1,500 individuals with chronic schizophrenia, was the high rate of treatment discontinuation (up to 74%) over the 18-month period of the trial and the short median time to discontinuation of treatment (about 6 months) in all phases of the trial.
What was the CATIE study?
The NIMH-funded Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Study was a nationwide public health-focused clinical trial that compared the effectiveness of older (first available in the 1950s) and newer (available since the 1990s) antipsychotic medications used to treat schizophrenia.
When was CATIE trial published?
The National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project: schizophrenia trial design and protocol development. Schizophr Bull. 2003;29(1):15-31.
Which of the following antipsychotic drug is typical?
Haldol (haloperidol) and Thorazine (chlorpromazine) are the best known typical antipsychotics. They continue to be useful in the treatment of severe psychosis and behavioral problems when newer medications are ineffective. However, these medications do have a high risk of side effects, some of which are quite severe.
What is the most common negative symptom of schizophrenia?
Negative mental symptoms
- a seeming lack of interest in the world.
- not wanting to interact with other people (social withdrawal)
- an inability to feel or express pleasure (anhedonia)
- an inability to act spontaneously.
- decreased sense of purpose.
- lack of motivation (avolition)
- not talking much.
Which negative symptom of schizophrenia is related to disruptions in speech?
In the case of schizophrenia, alogia involves a disruption in the thought process that leads to a lack of speech and issues with verbal fluency. For this reason, it is thought that alogia that appears as part of schizophrenia may result from disorganized semantic memory.
What is amisulpride?
Amisulpride 100mg Tablets are indicated for the treatment of acute and chronic schizophrenic disorders, in which positive symptoms (such as delusions, hallucinations, thought disorders) and/or negative symptoms (such as blunted affect, emotional and social withdrawal) are prominent, including patients characterised by …
Are antipsychotics effective for delusions?
Antipsychotic medications can reduce or relieve symptoms of psychosis, such as delusions (false beliefs) and hallucinations (seeing or hearing something that is not there).
What is the brand name for perphenazine?
Formulations. It is sold under the brand names Trilafon (single drug) and Etrafon/Triavil/Triptafen (contains fixed dosages of amitriptyline). A brand name in Europe is Decentan pointing to the fact that perphenazine is approximately 10-times more potent than chlorpromazine.
What is the most powerful antipsychotic?
Clozapine, which has the strongest antipsychotic effect, can cause neutropenia. A problem in the treatment of schizophrenia is poor patient compliance leading to the recurrence of psychotic symptoms.
What is the oldest antipsychotic drug?
Chlorpromazine was the first antipsychotic and was followed by a large number of other antipsychotics, many with diverse chemical structures.