What are normal serotonin levels in urine?
Measure 5-hydroxyindoleacetic acid (5-HIAA), the end product of serotonin metabolism, in a 24-hour urine collection. Normal excretion ranges from 2 to 8 mg/day….Table 1.
| 5-HIAA, urine | Serotonin, blood |
|---|---|
| >100 mg/day | 790-4500 ng/mL |
What does high serotonin in urine mean?
Serotonin is a hormone that plays a role in transmitting nerve impulses. It also affects your sleep and mood. Your body normally gets rid of 5-HIAA in your urine. You may have higher levels of 5-HIAA in your urine if you have a carcinoid tumor. These tumors secrete serotonin.
What is the normal range for 5-HIAA?
The normal range is 2 to 9 mg/24h (10.4 to 46.8 µmol/24h). Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your provider about the meaning of your specific test results.
What would high levels of 5-HIAA indicate?
24-hour urine 5-HIAA test With elevated values, levels greater than 25 mg/24 h or greater than 131 µmol/day indicate large carcinoid tumors, especially when in ileal, biliary, pancreatic, or duodenal tumors.
How accurate is 5-HIAA urine test?
Urine 5-HIAA has been shown to have a sensitivity of 73% and specificity of 100% for diagnosing well-differentiated functional gastroenterohepatic neuroendocrine tumors.
What is 5-HIAA urine test for?
This test measures the level of 5-HIAA in the urine. It is often done to detect certain tumors in the digestive tract (carcinoid tumors) and to track a person’s condition. The urine test may also be used to diagnose a disorder called systemic mastocytosis and some tumors of the hormone.
What could cause a false positive result in a urine 5-HIAA test?
False-positive 24-hour urine 5-HIAA results may be induced by the ingestion of tryptophan/serotonin-rich foods (pineapple, banana, kiwi, plum, tomato, avocado, walnut, eggplant, hickory nut, etc.), and certain medications and supplements such as acetaminophen, nicotine, and caffeine (5,6).
What disease may be associated with decreased 5-HIAA levels?
Diseases or disorders that display lower than normal urinary 5-hydroxy indoleacetic acid levels include obsessive-compulsive disorder, aromatic L-amino acid decarboxylation deficiency, sepiapterin reductase deficiency, and multiple sclerosis.
What does a 5-HIAA test for?
5-HIAA is a urine test that measures the amount of 5-hydroxyindoleacetic acid (5-HIAA). 5-HIAA is a breakdown product of a hormone called serotonin. This test tells how much 5-HIAA the body is producing. It is also a way to measure how much serotonin is in the body.
Which organ is affected due to the deficiency of serotonin?
Low levels of serotonin in the brain may cause depression, anxiety, and sleep trouble. Many doctors will prescribe a selective serotonin reuptake inhibitor (SSRI) to treat depression.
What does low serotonin feel like?
People who feel unusually irritable or down for no apparent reason may have low serotonin levels. Depression: Feelings of sadness, hopelessness, and anger, as well as chronic fatigue and thoughts of suicide, may indicate depression. Anxiety: Low serotonin levels may cause anxiety.