Is thiocyanate a nucleophile?
The thiocyanate ion is a ‘pseudohalide’ and potent nucleophile that can react either via the nitrogen atom or sulfur atom. It has been widely use to prepare organic thiocyanates and a range of other sulfur containing compounds (Scheme 1).
What is thiocyanate used for?
In the early 20th century, thiocyanate was used in the treatment of hypertension, but it is no longer used because of associated toxicity. Sodium nitroprusside, a metabolite of which is thiocyanate, is however still used for the treatment of a hypertensive emergency.
Is potassium thiocyanate soluble?
Potassium thiocyanate is the chemical compound with the molecular formula KSCN. It is an important salt of the thiocyanate anion, one of the pseudohalides….Potassium thiocyanate.
| Names | |
|---|---|
| Solubility in water | 177 g/100 mL (0 °C) 217 g/100 mL (20 °C) |
| Solubility | acetone: 21.0 g/100 mL ethanol: soluble |
| Magnetic susceptibility (χ) | −48.0·10−6 cm3/mol |
How is thiocyanate produced?
As discussed earlier, thiocyanate is formed from the binding of cyanide and thiosulfate. Thiocyanate is 100-fold less toxic than cyanide and is excreted by the kidney with an approximate elimination half-life of 2.7 days.
Is thiocyanate Ambident Nucleophile?
The thiocyanate anion is an ambident nucleophile 1 which may react with electrophiles at sulfur to give thiocyanates or at nitrogen to give isothiocyanates (Scheme 1).
What compound is SCN?
THIOCYANATE ION
SCN : Summary
| Code | SCN |
|---|---|
| One-letter code | X |
| Molecule name | THIOCYANATE ION |
| Systematic names | Program Version Name ACDLabs 10.04 thiocyanate OpenEye OEToolkits 1.5.0 thiocyanate |
| Formula | C N S |
What is iron III thiocyanate used for?
Oxidation of ferrous to ferric ion and subsequent complexation of the latter by thiocyanate is known as ferric thiocyanate assay and is used for determination of presence of various oxidizers, such as lipid hydroperoxides, and evaluation of effects of antioxidants.
Can thiocyanate form linkage isomers?
Linkage isomerism is the existence of coordination compounds that have the same composition differing with the connectivity of the metal to a ligand. Typical ligands that give rise to linkage isomers are: thiocyanate, SCN− – isothiocyanate, NCS.
What happens if you eat potassium thiocyanate?
Potassium thiocyanate is a chemical that is skin and eye irritant and is highly toxic when ingested in a body. Direct eye contact will cause redness and a lot of pain. And direct skin contact will cause irritation in the local areas. Ingestion in the body will cause headache, dizziness, nausea, vomiting, and faintness.
How much potassium thiocyanate is lethal?
Probable lethal dose of thiocyanate (rhodanate), in man, is between 15 and 30 gm (ingested at one time).
How is thiocyanate toxicity treated?
Thiocyanate toxicity Thiocyanate is usually excreted in the urine. Toxicity can be minimized by avoiding prolonged administration of nitroprusside and by limiting drug use in patients with renal insufficiency. If necessary, thiocyanate can be removed by dialysis.