Does medulloblastoma metastasize?
While the spread of malignant brain tumors is usually limited to the CNS, medulloblastomas can aggressively metastasize into extraneural tissues.
What is medulloblastoma prognosis?
Overall, the survival rate for children with medulloblastoma that has not spread is about 70% to 80%. The survival rate if the medulloblastoma has spread to the spinal cord is about 60%.
What is leptomeningeal dissemination?
Leptomeningeal dissemination (LMD) is the defining pattern of metastasis for medulloblastoma. Although LMD is responsible for virtually 100% of medulloblastoma deaths, it remains the least well-understood part of medulloblastoma pathogenesis.
What stage of cancer is medulloblastoma?
Medulloblastomas are all classified as Grade IV tumors. This means they are malignant (cancerous) and fast-growing.
Can you survive Leptomeningeal disease?
Despite advances in targeted radiation and chemotherapy, survival remains poor after diagnosis of leptomeningeal involvement, averaging 3–6 months. Survival varies by etiology, with breast cancer patients having the best prognosis (13–25% survival at one year and 6% at two years) [1, 4, 5].
Does medulloblastoma run in families?
The exact cause of medulloblastoma is not known. It does not seem to “run in families.” However, there is a higher risk of medulloblastoma with some genetic syndromes, such as Gorlin’s syndrome and Turcot’s syndrome.
Can you fully recover from medulloblastoma?
If you experience a tumor recurrence, you will need to get treatment for the tumor again. This recovery process may take a few years and often includes physical and occupational therapy. Many children and adults recover from medulloblastoma and gain the ability to live a normal and productive life.
Can leptomeningeal metastases be cured?
Goals for treatment include prolonging survival and stabilizing neurological symptoms. While there’s no cure for leptomeningeal disease yet, radiation and chemotherapy are the two most common treatments.
What does leptomeningeal feel like?
Leptomeningeal disease may also be referred to as carcinomatous meningitis or neoplastic meningitis. Most often with this complication, people have multiple neurological symptoms including visual changes, speech problems, weakness or numbness of one side of the body, loss of balance, confusion, or seizures.