Can statins affect asthma?
Comparing Studies In that study, 24 patients who were starting statins saw significant drops in lung function, needed more medication, had more nighttime asthma problems, and were seen in the office more frequently compared to 26 patients who were not taking those medications.
Is simvastatin a vasodilator?
Simvastatin, associated or not to L-arginine, did not affect ADMA levels and endothelium-dependent vasodilation. Our data showed that simvastatin reduced the plasma concentrations of NOx and RSNO without affecting either the levels of ADMA or endothelium-dependent vasodilation in hypercholesterolemia.
Which statins are prodrugs?
Lovastatin and simvastatin are prodrugs and must be hydrolyzed to the active hydroxy acid, while other statins are administered in the active hydroxy acid form. All statins are subject to extensive first-pass metabolism with the exception of pravastatin.
Is simvastatin well tolerated?
Simvastatin and atorvastatin were well tolerated at the doses studied.
Can simvastatin cause breathing problems?
Simvastatin was the most common statin reported to cause lung injury, found in six cases. The time from the start of statin treatment to the onset of lung injury varied widely, ranging from 0.25 to 120 months (mean±SD, 34.3±34.9 months).
Can statins make it hard to breathe?
If you feel short of breath or develop an unexplained cough. This is because (in very rare cases), atorvastatin may cause a disease called interstitial lung disease. If you develop any allergic-type reactions, such as swelling around your mouth or face, or a skin rash.
Do statins dilate blood vessels?
Statins also helped to dilate blood vessels leading to improved blood flow and lower stress on the heart.
Are statins vasodilators?
6 Conclusion. Statins have enhanced endothelium-dependent vasodilation and dose-dependently decreased smooth muscle cells migration and proliferation, independently of their ability to reduce plasma cholesterol.
Why is simvastatin a prodrug?
Because the liver is the major site of cholesterol synthesis, it is the primary target of the class of drugs known as HMG-CoA reductase inhibitors. Simvastatin (SV) is a lactone prodrug which undergoes reversible metabolism. In the hydroxy acid form (SVA) it is a potent inhibitor of HMG-CoA reductase.
What is the pharmacokinetics of simvastatin?
Simvastatin is well absorbed (about 60–80%) after oral administration, but it undergoes extensive first-pass metabolism by the hepatic CYP3A4 system [10]. The bioavailability of active HMG-CoA reductase inhibitors following simvastatin tablets is <5% of the oral dose.
Why are doctors pushing statins?
Statins are among the most prescribed medications because they have a mountain of evidence that they lower the risk of heart attack, stroke, and death in those at high risk for heart disease.
Are statins worth the risk?
While statins are highly effective and safe for most people, they have been linked to muscle pain, digestive problems and mental fuzziness in some people who take them and may rarely cause liver damage.
What are the bad side effects of simvastatin?
headache;
Is simvastatin a good drug?
Simvastatin (Zocor) is an inexpensive drug used to lower levels of cholesterol and triglycerides in the blood. Simvastatin may also reduce the risk of heart attack or stroke in patients with risk factors for heart disease. This drug is slightly more popular than comparable drugs.
When should I take simvastatin?
Simvastatin is usually taken at bedtime or with an evening meal. If you take simvastatin more than once daily, take it with meals. Your doctor may occasionally change your dose to make sure you get the best results. While using simvastatin, you may need frequent blood tests at your doctor’s office.
How effective is simvastatin?
Clinical Studies in Adults. Simvastatin significantly slowed the progression of lesions as measured in the Year 4 angiogram by both parameters, as well as by change in percent diameter stenosis. In addition, Simvastatin significantly decreased the proportion of patients with new lesions and with new total occlusions.