What is thyroglobulin proteolysis?

What is thyroglobulin proteolysis?

Thyroglobulin is a large globular glycoprotein (approximate MW = 660,000) produced by follicular cells of the thyroid gland. Post-translational iodination and proteolysis of thyroglobulin produces the two iodine containing hormones of the thyroid, triiodothyronine (T3) and thyroxine (T4).

What are high levels of thyroglobulin?

Very high levels of thyroglobulin may suggest metastatic or recurrent disease. About one-fourth of patients who have thyroid cancer have antibodies to thyroglobulin. Antibodies should be checked along with thyroglobulin because if they are present, they could interfere with measurement of thyroglobulin.

What is a normal thyroglobulin count?

The normal range for thyroglobulin is: 1.40 – 29.2 ng/mL (μg/L) for men. 1.50 – 38.5 ng/mL for women.

Where does thyroglobulin proteolysis occur?

The release of T4 and T3 from the prohormone thyroglobulin (Tg) occurs in thyroid lysosomes.

What is serum thyroglobulin?

Thyroglobulin (Tg) is a storage form of thyroxine (T4) and triiodothyronine (T3). It is synthesized only by thyroid follicular cells and released into serum along with the thyroid hormones. Given the cellular specificity of Tg, its detection in biopsy specimens provides proof of the thyroid origin of the tissue.

What happens if thyroglobulin antibody is high?

If you have high levels of antithyroglobulin antibodies in your blood, it may be a sign of serious autoimmune disorder, such as Graves’ disease or Hashimoto thyroiditis. In some cases, you may have antithyroglobulin antibodies in your blood without any specific complications.

What causes high thyroglobulin antibodies?

Thyroglobulin antibodies may be found in people who have a thyroid problem. You may have an underactive thyroid (hypothyroidism) or overactive thyroid (hyperthyroidism). Thyroglobulin antibodies attack thyroglobulin proteins and can destroy the thyroid gland.

What causes elevated thyroglobulin?

Certain factors, such as gene defects, virus infection, iodine intake, stress or destruction of thyroid follicles caused by thyroid nodules (such as patients in high Tg group in the present study) and cancer, can lead to a raise of Tg level (30, 41, 42).

Do thyroglobulin levels fluctuate?

Serum Tg was measured and compared to imaging findings. After treatment initiation, serum Tg levels dropped in all patients with a median reduction of 86.2%. During long-term follow-up (median, 25.2 months), fluctuations in Tg could be observed in 8/9 subjects.

What causes thyroid antibodies to be high?

It can be caused by several conditions, including Hashimoto’s disease or Graves’ disease. Autoimmune disease, like lupus or rheumatoid arthritis. These and other disorders may raise your chance of having a thyroid problem.

What are symptoms of high thyroglobulin?

If you have an underlying thyroid condition, high thyroglobulin antibodies may be associated with the symptoms of that condition.

• Face and eye swelling.
• Fragile hair.
• Voice changes.