What is mannitol used for in tablets?

What is mannitol used for in tablets?

Mannitol (C6H8(OH)6) is used in pharmaceutical products as a sweeting agent, tablet and capsule diluent, excipient for chewable tablets, a tonicity agent, and as a vehicle (bulking agent) for lyophilized preparations. Mannitol is industrially derived from the sugar fructose, and is roughly half as sweet as sucrose.

Is mannitol a Disintegrant?

The need for prompt disintegration is met by formulating the ODT with mannitol, one of the only water soluble excipients that presents a delay in water adsorption. During this delay, saliva is fully available to enter the porous structure and for disintegrants or superdisintegrants to act.

Is mannitol a diluent?

3 Mannitol. Mannitol is a polyol isomer of sorbitol. It is a nonhygroscopic diluent and widely used in pharmaceutical preparations at concentrations of 10%–90% w/w.

Is mannitol used as tablet binder?

Due to these many favorable attributes, mannitol is finding increasing use as a pharmaceutical binder and thus becoming a standard excipient in formulations intended for wet granulation (as well as other processing routes).

Why is mannitol added to drugs?

Mannitol is a diuretic used to force urine production in people with acute (sudden) kidney failure. Mannitol injection is also used to reduce swelling and pressure inside the eye or around the brain. Mannitol is available under the following different brand names: Osmitrol.

Is mannitol a high risk medication?

Mannitol (mannitol (mannitol injection) injection) injection may increase cerebral blood flow and the risk of postoperative bleeding in neurosurgical patients. For intravenous use only.

Is haloperidol a tranquilizer?

Haloperidol is one of the most commonly used members of the butyrophenone class of neuroleptic major tranquilizers. It has a moderately rapid rate of onset, with a t1/2α of 3 to 19 minutes and a t1/2β of 10 to 19 hours. Respiratory depression and hypotension rarely occur.