What is AUC MIC ratio?

What is AUC MIC ratio?

A ratio of the vancomycin area under the concentration-time curve to the MIC (AUC/MIC) of ≥400 has been associated with clinical success when treating Staphylococcus aureus pneumonia, and this target was recommended by recently published vancomycin therapeutic monitoring consensus guidelines for treating all serious S.

How is vancomycin AUC calculated?

The calculation determines the AUC24 to be 349 µg/mL x hr (outside the target range). If using the Sanford Guide vancomycin calculator, the daily dose range that will achieve the target AUC24 of 400-600 µg/mL x hr is reported.

What does AUC over MIC mean?

AUC:MIC – A combination of both T>MIC and Peak:MIC. The rate of bacterial killing is both related to the amount of time above the MIC and the total exposure of antibiotic to the organism. Prototypical antibiotic: fluoroquinolones.

What is AUC vancomycin dosing?

AUC vancomycin dosing represents the total vancomycin concentration in the blood over a period of time, usually over 24 hours. In order to calculate this manually: Two vancomycin levels need to be drawn when the patient’s vancomycin is at a stable concentration, usually referred to as steady-state.

What is MIC dilution?

The MIC, or minimum inhibitory concentration, is the lowest concentration (in μg/mL) of an antibiotic that inhibits the growth of a given strain of bacteria.

How do you calculate true vancomycin trough?

The value of the measured trough (MT) was then extrapolated to estimate the true trough (TT), using the equation: TT = MT × e−Kt. With this method of determining vancomycin K, it is important to use an uncorrected value of CrCl in mL/min, not one that has been corrected to a standard body surface area of 1.73 m2.

How is vancomycin clearance calculated?

Clearance

1. CLvanco (mL/min/kg) = ([CrCl × 0.0075] + 0.04)
2. Vd = 0.47 L/kg. Vd was estimated using an adjusted body weight (ABW).

How do you calculate AUC score in Excel?

The formula for calculating the AUC (cell H18) is =SUM(H7:H17)….Figure 1 – ROC Table and Curve.

Cell	Meaning	Formula
H9	AUC	=(F9-F10)*G9

How do you calculate MIC?

1. Determination of minimal inhibitory concentrations (MICs)
2. Weight of powder (mg) =
3. Volume of solvent (ml) X Concentration (µg/ml) / Potency of powder (µg /mg)