What food can cause a false high for 5-HIAA if eaten within four days of the test?
Foods rich in serotonin such as avocados, bananas, pineapples, plums, cantaloupes, grapefruits, plantains, melons, kiwi fruits, walnuts, hickory nuts, butternuts, pecans, tomatoes, and eggplants can interfere with 5-HIAA measurement and should be avoided for 3 days prior to and during sample collection.
What were your symptoms of carcinoid syndrome?
The symptoms of carcinoid syndrome include episodes of warmth and redness of the face, head and upper chest; diarrhea; marked changes in blood pressure (usually hypotension, a decrease in blood pressure); asthmatic-like wheezing; weight loss or gain; malnutrition; dehydration; weakness; muscle and joint aching; and …
Which of the following causes an elevated 5-HIAA in a 24 hour urine collection?
False-positive 24-hour urine 5-HIAA results may be induced by the ingestion of tryptophan/serotonin-rich foods (pineapple, banana, kiwi, plum, tomato, avocado, walnut, eggplant, hickory nut, etc.), and certain medications and supplements such as acetaminophen, nicotine, and caffeine (5,6).
What causes elevated chromogranin A?
CgA levels may be elevated in conditions such as liver disease, inflammatory bowel disease, pancreatitis, chronic bronchitis, renal insufficiency, and stress. These possible causes for elevated CgA levels should be considered when interpreting test results.
What is the most common symptom of carcinoid syndrome?
The most common signs and symptoms include:
- Skin flushing. The skin on your face and upper chest feels hot and changes color — ranging from pink to purple.
- Facial skin lesions. Purplish areas of spiderlike veins may appear on your nose and upper lip.
- Diarrhea.
- Difficulty breathing.
- Rapid heartbeat.
How long can you live with carcinoid syndrome?
5-year relative survival rates for GI carcinoid tumors
| SEER Stage | 5-Year Relative Survival Rate |
|---|---|
| Localized | 97% |
| Regional | 95% |
| Distant | 67% |
| All SEER stages combined | 94% |
What happens if Chromogranin is high?
Impaired kidney function. Elevated CgA also occurs in the case of impaired kidney function due to reduced renal clearance. The higher the degree of renal failure, the higher the CgA concentration, and the result may reach the level found in neuroendocrine tumors [13].
What does high serum chromogranin mean?
An increased Chromogranin A level in a person with symptoms may indicate the presence of a tumor, but it is not specific for the type of tumor or its location. In order to diagnose the condition, the tumor itself must be located, biopsied, and examined by a pathologist.
Is there a correlation between serum and urine 5-HIAA levels?
Conclusion: We have demonstrated a strong correlation between serum and urine 5-HIAA results. In patients with 5-HIAA concentrations above the reference range, the increase in serum 5-HIAA is greater than that of urinary 5-HIAA, indicating that plasma 5-HIAA may be preferable in the diagnosis and monitoring of neuroendocrine tumours.
What is a 5HIAA test?
Plasma 5-hydroxy-indoleacetic acid (5HIAA or 5-HIAA) is a metabolite of serotonin that can be elevated as a result of carcinoid tumors/carcinoid syndrome. This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
What causes 5-HIAA to be high?
Urinary 5-HIAA levels may be increased in malabsorption syndromes, as well as after ingestion of certain drugs or food containing serotonin (2,16). As well, the sensitivity of 5-HIAA urinary level varies depending on the type of carcinoid being detected (17).
What is the normal range for 5 HIAA?
The normal range for urinary 5- hiaa is 3–15 mg/24 h, but the figure may vary depending on the laboratory. Up to 45 mg/24 h is considered normal by some laboratories. Levels of 5- hiaa have no clear correlation with symptoms, but they do fluctuate with symptomatology.