Is fibroblastoma cancer?
Collagenous fibroma, also known as desmoplastic fibroblastoma, is a rare, benign soft tissue tumor first described by Evans (1) in 1995. It belongs to the fibroblastic/myofibroblastic tumor group according to the 2013 World Health Organization Classification of Soft Tissue Tumors (2).
What is a giant cell pathology?
giant cell, also called Langhans giant cell, large cell characterized by an arc of nuclei toward the outer membrane. The cell is formed by the fusion of epithelioid cells, which are derived from immune cells called macrophages.
What is the juvenile form of dermatofibrosarcoma protuberans?
Giant Cell Fibroblastoma (GCF, Juvenile Dermatofibrosarcoma Protuberans)
What is Dermatofibrosarcoma?
Dermatofibrosarcoma protuberans (DFSP) is a very rare type of skin cancer that begins in connective tissue cells in the middle layer of your skin (dermis). Dermatofibrosarcoma protuberans may at first appear as a bruise or scar. As it grows, lumps of tissue (protuberans) may form near the surface of the skin.
What is Desmoplastic Fibroblastoma?
Desmoplastic fibroblastoma is a relatively rare, distinctive, benign, fibrous soft-tissue tumor that originally was described in a report of seven cases published in the American Journal of Surgical Pathology in 1995 by Evans [1], who differentiated it from other fibrous soft-tissue tumors.
What is a Fibroelastoma?
ANSWER: Fibroelastomas are formally known as papillary fibroelastomas, or PFEs, and are sometimes called cardiac papillomas. These small, noncancerous tumors develop in the heart — most often on one of the valves located between the heart chambers.
What is the purpose of giant cells?
Their differentiation into macrophages is crucial for a broad array of immunologic processes that regulate inflammation, neoplasia, and infection. In certain pathologic conditions, such as foreign body reactions and peripheral inflammatory lesions, monocytes fuse to form large, multinucleated giant cells (MGCs).
What is giant cell tumor?
A giant cell tumor is a rare, aggressive non-cancerous tumor. It usually develops near a joint at the end of the bone. Most occur in the long bones of the legs and arms. Giant cell tumors most often occur in young adults when skeletal bone growth is complete.
Can dermatofibrosarcoma protuberans metastasis?
Dermatofibrosarcoma protuberans (DFSP) is a tumor that develops in skin or subcutaneous tissue and is characterized by a protuberant growth pattern [1]. DFSP often recurs locally after surgery, but rarely metastasizes to distant sites and is classified as a sarcoma of intermediate-grade malignancy [2–7].
What does dermatofibrosarcoma protuberans look like?
It often looks like a scar or wrinkled patch of skin that may be violet, reddish brown or skin-colored. Rarely, DFSP presents as a soft, depressed area of skin, which makes the diagnosis even more difficult. As DFSP grows, a violet, reddish brown or skin-colored tumor may appear, sometimes more than one.
Is Dermatofibrosarcoma curable?
The general prognosis for DFSP is excellent. In the past, recurrence rates were high, but with the introduction of Mohs surgery, those rates have decreased. Even with recurrent DFSP, Mohs surgery has a 98% cure rate. A poor prognosis is associated with metastasis.
What is fibroma of tendon sheath?
Fibroma of the tendon sheath (FTS) is a rare, benign, soft tissue lesion. Clinically, FTS presents similarly to the more common giant cell tumor of the tendon sheath. It is distinguished histologically by the lack of giant cells, foamy histiocytes and synovial cells.
What is the history of giant cell fibroblastoma (GCF)?
A quarter of a century ago at the International Academy of Pathology in Boston, Mass, Drs Enzinger and Shmookler’s seminal abstract on giant cell fibroblastoma (GCF) included 20 GCFs on the back and thigh of mostly male children. These tumors involved dermis and subcutis, and had parallel fascicles …
What is fibroblastic tumor with floret-like giant cells?
Accessed January 5th, 2022. Rare childhood fibroblastic tumor of intermediate malignancy with floret-like giant cells and ectatic pseudovascular spaces lined by stromal cells and giant cells Poorly circumscribed, gray to yellow mucoid mass that is difficult to completely excise, usually in subcutis
Which tumors are associated with giant cell carcinoma?
Other tumors that exhibit giant cells, such as giant cell carcinoma of the bladder, urothelial carcinoma with osteoclast-type giant cells or trophoblastic differentiation, and leiomyosarcoma with frank nuclear anaplasia, should also be considered.
What is giant cell angiofibroma (GCA)?
Giant cell angiofibroma is a rare soft tissue tumor that was first described in the orbit. Since then, several case reports have described this tumor at various extraorbital sites, including the submandibular region, the parascapular area, and the posterior mediastinum.