How is hypothermia neuroprotective?
Although the neuroprotective mechanisms of hypothermia in different diseases vary and have yet to be fully determined, the neuroprotection has been commonly ascribe to its effect on decreasing the metabolic rate, reducing the generation of radicals, ameliorating inflammation, inhibiting excitotoxicity and apoptosis.
How does therapeutic hypothermia protect the brain?
The basic mechanisms through which hypothermia protects the brain are clearly multifactorial and include at least the following: reduction in brain metabolic rate, effects on cerebral blood flow, reduction of the critical threshold for oxygen delivery, blockade of excitotoxic mechanisms, calcium antagonism.
Why is hypothermia protocol used?
Therapeutic hypothermia is a type of treatment. It’s sometimes used for people who have a cardiac arrest. Cardiac arrest happens when the heart suddenly stops beating. Once the heart starts beating again, healthcare providers use cooling devices to lower your body temperature for a short time.
How do you induce therapeutic hypothermia?
In general, two methods of induced hypothermia are used currently: surface cooling and endovascular cooling. Surface cooling methods include convective air blankets, water mattresses, alcohol bathing, cooling jackets, and ice packing. Surface cooling techniques have been used for many years in the treatment of fever.
When do you initiate targeted temperature management?
Targeted temperature management should be started as soon as possible. The goal temperature should be reached before 8 hours. Targeted temperature management remains partially effective even when initiated as long as 6 hours after collapse.
What is the recommended target temperature therapeutic hypothermia?
(TTM) Targeted Temperature Management The optimum temperature for therapeutic hypothermia is 32-36 ° C (89.6 to 96.8 ° F). A single target temperature, within this range, should be selected, achieved, and maintained for at least 24 hours.
Is therapeutic hypothermia effective?
Compared with untreated patients, those treated with therapeutic hypothermia had significantly lower rates of in-hospital survival (29.2% vs 27.4%, respectively), as well as lower rates of survival to discharge with favorable neurological status.
What is targeted temperature management ACLS?
OVERVIEW. Targeted temperature management (TTM) refers to strict temperature control following cardiac arrest. Current evidence suggests TTM after cardiac arrest (CA) improves neurologically intact survival, though the mechanism is uncertain.
What methods are used for targeted temperature management?
Most studies have found it necessary to use both cooling blankets and ice packs to achieve the temperature goal. Other methods such as ice lavage, cold saline infusion, and endovascular methods may be used to help achieve target temperature.
When should you not do targeted temperature management?
A temperature below 30 °C (86 °F) should be avoided, as adverse events increase significantly. The person should be kept at the goal temperature plus or minus half a degree Celsius for 24 hours. Rewarming should be done slowly with suggested speeds of 0.1 to 0.5 °C (0.18 to 0.90 °F) per hour.
What is Arctic sun therapy?
The Arctic Sun has been explained as dry water immersion. It is a non-invasive precision temperature management system that is used to induce hypothermia in comatose patients that have suffered from Sudden Cardiac Arrest (SCA) and patients at risk for ischemic brain damage.
What is the recommended duration of therapeutic hypothermia?
The optimum temperature for therapeutic hypothermia is 32-36 ° C (89.6 to 96.8 ° F). A single target temperature, within this range, should be selected, achieved, and maintained for at least 24 hours.