Do Australian Shepherds have MDR1?
Many herding breeds (most commonly Collies and Australian Shepherds) have a mutation at the MDR1 gene that makes them more sensitive to the negative effects of certain medications. Dogs with MDR1 mutations will show negative effects from these drugs at doses that are readily tolerated by dogs without the mutation.
What is a MDR1 carrier in dogs?
Dog is a carrier for the MDR1 mutation, and can pass on a copy of the defective gene to its offspring 50% 0f the time. Dog tested negative for the MDR gene mutation, and will not pass on the defective gene to its offspring.
Is Heartgard safe for MDR1 dogs?
All heartworm preventive medications can affect dogs with the MDR1 mutation, including ivermectin (Heartgard), milbemycin (Interceptor, Sentinel), selamectin (Revolution), and moxidectin (ProHeart, Advantage Multi). I recommend using commercial heartworm preventatives under the direction of a veterinarian.”
Do Australian cattle dogs have the MDR1 gene?
Multidrug resistance is a genetic defect in a gene called MDR1. If your Australian Cattle Dog has this mutation, it can affect his processing of many drugs, including substances commonly used to treat parasites, diarrhea and even cancer.
What percentage of Aussies have MDR1?
Worldwide, the percentage of Australian shepherds which inherited one copy of the mutation ranged from 25% to 44% and the percentage of the breed which inherited two copies of the mutation associated with MDR1 ranged from 10% to 25%.
How common is MDR1 in Australian Shepherds?
A Herding Dog Gene
| BREED | APPROXIMATE FREQUENCY (%) |
|---|---|
| Australian shepherd | 50 |
| Australian shepherd, mini | 50 |
| McNab collie | 30 |
| Silken windhound | 30 |
How common is MDR1 in Australian shepherds?
What heartworm medicine is safe for Australian shepherds?
Ivermectin
Collies and Ivermectin Safety Ivermectin, when dosed at the low dosage ranges necessary to prevent infection with heartworms, is generally considered to be safe for dogs of all breeds, including Collies, Shelties, Australian Shepherds, and English and Old English Sheepdogs.
Do not use drugs for Australian shepherds?
Australian Shepherds, along with several other mostly collie-type breeds, can carry a genetic mutation that makes them sensitive to certain drugs. Use of those drugs can cause serious neurological illness or death.
What is the MDR1 gene in Australian shepherds?
Multi-Drug Resistance 1
MDR1 is the abbreviated name of a gene called Multi-Drug Resistance 1. A mutation of this gene causes sensitivity to Ivermectin and a number of other drugs. Dogs with the mutation will react to those drugs. Whether a dog reacts depends on the dosage of the drug.
Is MDR1 serious?
However, if she has the MDR1 mutation—also known as multi-drug sensitivity—her cells will fail to clear the medications from the brain like a normal dog would. In more severe cases when a dog carries two copies of the MDR1 mutation, this drug sensitivity can be life-threatening.
Can Aussies have ivermectin?
Ivermectin, when dosed at the low dosage ranges necessary to prevent infection with heartworms, is generally considered to be safe for dogs of all breeds, including Collies, Shelties, Australian Shepherds, and English and Old English Sheepdogs.