What is PVR in cancer?
PVR is dramatically overexpressed in several human malignancies, whereas its expression is low or absent in most healthy tissues. Consistent with PVR biology, its overexpression promotes tumor cell invasion, migration, and proliferation and is associated with a poor prognosis and enhanced tumor progression.
What does CD155 do?
CD155 is an adhesion molecule belonging to the Nectin/Nectin-like family often overexpressed on tumor cells and involved in many different processes such as cell adhesion, migration and proliferation.
Which cells express CD155?
3, is expressed by human NK cells, T cells, a subset of B cells, monocytes and platelets (Lanier, 2005). CD155 (also known as polio virus receptor [PVR]) and CD112 (also called nectin-2) have been identified as ligands for DNAM-1 (Bottino et al., 2003).
Where are poliovirus receptors found?
Polioviruses have an attachment site at a depression on their surface, known as a canyon-like receptor (Tuthill et al., 2010).
What is PVR in biology?
The human poliovirus receptor (PVR) is a cell surface protein with a multitude of functions in human biology. Through its interactions with CD226 and TIGIT, transmembrane proteins found on leukocytes, PVR is a key regulator of the cell-mediated immune response.
Is polio A virus bacteria or fungi?
Polio is a viral infection that can cause paralysis and death in its most severe forms. It can spread easily from person to person.
What is the structure of poliovirus?
Polioviruses are single-stranded RNA viruses belonging to the family Picornaviridae. They have a naked protein capsid with a dense central core. The capsid consists of four structural proteins, VP1, VP2, VP3, and VP4. The genomic RNA is approximately 7440 to 7500 nucleotides in length.
How does poliovirus bind to CD155?
The human receptor for poliovirus (CD155) is an immunoglobulin-like molecule with unknown normal function(s). Here we provide evidence that CD155 binds specifically to vitronectin with a dissociation constant (K(d)) of 72 nM as determined by surface plasmon resonance.
How does poliovirus enter the cell?
By testing inhibitors known to target specific enzymes, future studies can determine which one poliovirus hijacks to infect cells. Altogether, these results suggest that the poliovirus enters the cell after binding to the cell surface, then rapidly releases it genome from vesicles near the membrane.
What is the root cause of polio?
Polio is caused by 1 of 3 types of the poliovirus. It often spreads due to contact with infected feces. This often happens from poor handwashing. It can also happen from eating or drinking contaminated food or water.
What is the role of CD155 in the pathophysiology of cancer?
Cd155-/- mice displayed reduced tumor growth and metastasis via DNAM-1 upregulation and enhanced effector function of CD8+ T and NK cells, respectively. CD155-deleted tumor cells also displayed slower tumor growth and reduced metastases, demonstrating the importance of a tumor-intrinsic role of CD155.
What is cdcd155?
CD155 is an adhesion molecule belonging to the Nectin/Nectin-like family often overexpressed on tumor cells and involved in many different processes such as cell adhesion, migration and proliferation.
Is cdcd155 down-regulated by post-translational modifications in tumor cells?
CD155 surface expression on tumor cells may also be down-regulated by post-translational modifications [57], as previously shown for several immune receptors [58,59,60].
What is CD155 (pvr/necl5/tage4)?
Electronic address: [email protected]. CD155 (PVR/necl5/Tage4), a member of the nectin-like family of adhesion molecules, is highly upregulated on tumor cells across multiple cancer types and has been associated with worse patient outcomes.
https://www.youtube.com/watch?v=lphgSRcdnlg