Is ADAM8 a marker of CML?

Is ADAM8 a marker of CML?

ADAM8 is a marker of residual CML cells. Authors conclude that ADAM8 promotes early metastatic processes such as transendothelial migration by upregulation of MMP-9 and shedding of PSGL-1 from breast cancer cells. ADAM8 on leukocytes holds a proinflammatory function in acute lung inflammation by promoting alveolar leukocyte recruitment.

What does ADAM8 stand for?

ADAM8 ADAM metallopeptidase domain 8 [ (human)] Gene ID: 101, updated on 8-Dec-2016. This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family.

Is ADAM8 a target of miR-328?

Study in human pancreatic cancer cells demonstrated that ADAM8 was a direct target of miR-328. Knockdown of miR-328 or ADAM8 led to significantly decreased cell growth and viability. Blood ADAM 8 is a promising biomarker for early detection of gastric cancer. ADAMs binds to integrins to regulate cell adhesion and migration.

Is ADAM8 overexpressed in colorectal cancer?

Results show that ADAM8 is overexpressed in colorectal cancer and promotes cell growth. N-glycosylation is essential for processing, localization, stability, and activity of ADAM8. ADAM8 expression is increased in both severe asthma and COPD and associated with sputum total cell count and neutrophils.