What does ERCC1 gene do?
The ERCC1-XPF nuclease is an essential activity in the pathway of DNA nucleotide excision repair (NER). The ERCC1-XPF nuclease also functions in pathways to repair double-strand breaks in DNA, and in the repair of “crosslink” damage that harmfully links the two DNA strands.
What is ERCC1 cancer?
Excision repair cross-complementing group 1 (ERCC1) overexpression inhibits cell apoptosis and is associated with unfavorable prognosis of esophageal squamous cell carcinoma. Excision repair cross-complementing group 1 (ERCC1) functions as a nucleotide excision repair (NER) enzyme.
What is XPA gene?
The XPA gene provides instructions for making a protein that is involved in repairing damaged DNA. DNA can be damaged by ultraviolet (UV) rays from the sun and by toxic chemicals, radiation, and unstable molecules called free radicals.
What protein do the genes ercc5 XP G encode?
DNA endonuclease
“Human xeroderma pigmentosum group G gene encodes a DNA endonuclease”. Nucleic Acids Research. 22 (16): 3312–6. doi:10.1093/nar/22.16.
What enzymes are involved in nucleotide excision repair?
Excision repair involves removal of a damaged nucleotide by dual incisions bracketing the lesion; this is accomplished by a multisubunit enzyme referred to as the excision nuclease or excinuclease.
What is the protein ID of XPA gene?
DNA repair protein complementing XP-A cells is a protein that in humans is encoded by the XPA gene….
| XPA | ||
|---|---|---|
| Species | Human | Mouse |
| Entrez | 7507 | 22590 |
| Ensembl | ENSG00000136936 | ENSMUSG00000028329 |
| UniProt | P23025 | Q64267 |
What is XPA protein?
Xeroderma pigmentosum complementation group A (XPA) is an essential protein in the nucleotide excision repair (NER) pathway, the main DNA repair pathway responsible for the excision of bulky DNA lesions in both eukaryotic and prokaryotic cells.
What are the 3 steps of nucleotide excision repair?
The basic mechanism of excision repair involves: (1) damage recognition; (2) subunit assembly; (3) dual incisions that result in excision of the damage-containing oligomer; (4) resynthesis to fill in the gap; and (5) ligation to regenerate an intact molecule.
What does RAD51 do in homologous recombination?
In humans, RAD51 is a 339-amino acid protein that plays a major role in homologous recombination of DNA during double strand break repair. In this process, an ATP dependent DNA strand exchange takes place in which a template strand invades base-paired strands of homologous DNA molecules.