What does c-myc positive mean?
The expression of c-MYC and BCL2 in the “double-expressor” lymphomas is independent of c-MYC or BCL2 gene rearrangement [51,52], and is only used as a prognostic marker rather than diagnostic criteria. c-MYC expression is considered positive when >40% of the lymphoma cells are stained [49].
What is MYC in lymphoma?
MYC is a potent oncogene initially identified as the target of the t(8;14)(q24;q32) chromosome translocation in Burkitt lymphoma. MYC gene alterations have been identified in other mature B-cell neoplasms that are usually associated with an aggressive clinical behavior.
What is MYC gene rearrangement?
Purpose: MYC rearrangement (MYC-R) occurs in approximately 10% of diffuse large B-cell lymphomas (DLBCLs) and has been associated with poor prognosis in many studies. The impact of MYC-R on prognosis may be influenced by the MYC partner gene (immunoglobulin [IG] or a non-IG gene).
What result does c-myc have on transcription?
In cancer, c-myc is often constitutively (persistently) expressed. This leads to the increased expression of many genes, some of which are involved in cell proliferation, contributing to the formation of cancer….Myc.
| MYC proto-oncogene, bHLH transcription factor | |
|---|---|
| Identifiers | |
| NCBI gene | 4609 |
| HGNC | 7553 |
| OMIM | 190080 |
What is C-MYC translocation?
c-MYC is the prototype for oncogene activation by chromosomal translocation. In contrast to the tightly regulated expression of c-myc in normal cells, c-myc is frequently deregulated in human cancers.
What is CD20 positive?
CD20 positive T cell lymphoma is a rare condition that is characterized by the coexpression of CD20 and T cell markers, such as, CD3, CD5, or UCHL-11. Positivity for CD20 in any type of T cell lymphoma represents an aberrant immunophenotype, despite the presence of various indicators of T cell lymphoma.
What are 3 alterations in the MYC gene that have been observed in cancers and that result in MYC activation?
Such alterations include (1) point mutations in the MYC coding region that appear to increase MYC protein stability and activity as secondary events to translocations in lymphoma (Bahram et al., 2000, Hemann et al., 2005); (2) mutation or rare amplification of distal enhancers (Sur et al., 2012, Zhang et al., 2016); …
Why is immunohistochemistry important in B-cell lymphoma diagnosis?
Immunohistochemical pattern of c-MYC protein judged as “+/(weak)+/-” by a new notation correlates with MYC gene nontranslocation in large B-cell lymphoma Immunohistochemistry is not only the most important tool for pathologists to establish a final diagnosis, but it can also inform decisions regarding optimal treatment methods.
Does diffuse large B-cell lymphoma with double expression of c-Myc and BCL2 protein?
Background: Diffuse large B-cell lymphoma (DLBCL) with double expression of c-MYC and BCL2 protein is associated with dismal outcome after treatment with R-CHOP. Local data on disease burden and survival outcome in DLBCL is limited.
Are Bcl-2 and c-Myc elevated in primary central nervous system lymphoma (PCNSL)?
Overexpression of bcl-2 and c-myc are defining features of double-expressor-lymphoma (DEL) but may also occur separately in patients with primary central nervous system lymphoma (PCNSL). Despite all progress in optimizing treatment regimen, there is lack of sufficient risk stratification models.
How common is double expression of BCL2 and Myc?
Results: Through IHC, the expression of MYC, BCL2, and double expression was detected in 35.6%, 46.7% and 30% of patients, respectively. While by RT-PCR, it was 4.53±0.74 for MYC compared with 2.18±0.78 for BCL-2.