What is tgtg4001?

What is tgtg4001?

TG4001 is a therapeutic cancer vaccine candidate using an attenuated and modified poxvirus (MVA) as a vector expressing the HPV16 E6 and E7 proteins (rendered non-oncogenic) interleukin-2. TG4001 is developed in Human Papillomavirus (HPV)-16 positive cancers, such as cervical, vaginal, and oropharyngeal squamous cell carcinoma of the head and neck.

What are the key findings of the tg4001/avelumab trial?

Key findings of the trial: The combination of TG4001 and avelumab demonstrates anti-tumor activity (23.5% ORR) in patients with previously treated recurrent and/or metastatic HPV-related cancers; the Presence of liver metastases has a profound impact on outcome in terms of ORR and PFS.

Is Transgene’s TG4001 effective in hpv16-positive recurrent and/or metastatic malignancies?

On September 16, 2020, Transgene, previously known as Tipapkinogen Sovacivec, announced the analysis of the efficacy data from the Phase 1b/2 trial combining TG4001 with avelumab in HPV16-positive recurrent and/or metastatic malignancies showed promising clinical activity in the overall study population (34 evaluable patients).