Why are the telopeptide ends of collagen important?

Why are the telopeptide ends of collagen important?

This study has demonstrated that telopeptides significantly increase the complex shear modulus of collagen solutions in a frequency- and concentration-dependent manner.

What is collagen telopeptide?

Histidinohydroxylysinonorleucine (HHL) is a major stable trifunctional collagen cross-link in mature skin that involves a carboxyl terminal, telopeptide site 16c, the sixteenth amino acid residue from the carboxy terminal of the telopeptide region of alpha 1 (I) in type I collagen.

What is carboxy terminal collagen crosslinks?

The C-terminal telopeptide (CTX), also known as carboxy-terminal collagen crosslinks, is the C-terminal telopeptide of fibrillar collagens such as collagen type I and type II. It is used as a biomarker in the serum to measure the rate of bone turnover.

How do I prepare for a NTx urine test?

Preparation: No fasting required. Collection should be the second morning void. Test Results: 5-7 days. May take longer based on weather, holiday or lab delays.

What is C telopeptide collagen type1?

The cross-linked C-terminal telopeptide of type I collagen, or CTX-I, is a sensitive but also rather variable marker of bone resorption, and several assays for the cross-linked telopeptide are commercially available.

What does high C telopeptide mean?

Elevated levels of C-terminal telopeptide indicate increased bone turnover. Elevated levels are found in osteoporosis patients with elevated bone turnover who are at increased risk for rapid disease progression.

What is CTX collagen?

Collagen Type I C-Telopeptide (CTx) – CTx is useful to assess bone resorption in patients with metabolic bone disease. The test is also useful in monitoring therapy to slow or halt osteoporotic bone loss.

Is CTX test reliable?

We conclude that the serum CTX is not a valid preoperative test to accurately assess the level of risk of developing ONJ and is not indicated in the oral surgery patient.

What does my CTX score mean?

Elevated levels of beta-C-terminal telopeptide (CTx) indicate increased bone resorption. Increased levels are associated with osteoporosis, osteopenia, Paget disease, hyperthyroidism, and hyperparathyroidism.

What is a good NTx score?

The reference ranges for NTX in urine, as measured in nm BCE/mm creatinine, are as follows : Male: 21-83. Female (premenopausal): 17-94. Female (postmenopausal): 26-124.

What does a low NTx telopeptide mean?

Interpretation. Provides information to assist in interpretation of the test results. Elevated levels of N-terminal telopeptide (NTx) indicate increased bone resorption. Most patients with osteopenia or osteoporosis have low, but unbalanced, bone turnover, with bone resorption dominating over bone formation.

What is a good C telopeptide number?

The reference ranges for C-terminal telopeptide in serum are as follows : Female (premenopausal): 40-465 pg/mL. Female (postmenopausal): 104-1008 pg/mL. Male: 60-700 pg/mL.

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