Which chemo drugs cause cardiomyopathy?

Which chemo drugs cause cardiomyopathy?

Causes of Cardiomyopathy in Cancer Patients They include doxorubicin (Adriamycin® and Rubex®), daunorubicin (Cerubidine®), epirubicin (Ellence®), and idarubicin (Idamycin®). You’re more likely to get cardiomyopathy from these medications if you get high doses of them.

Is Taxol a cardiotoxic?

Paclitaxel has cardiotoxic effects. Careful monitoring of cardiac function during and after paclitaxel infusion is required in patients with high-risk features.

Is docetaxel a cardiotoxic?

Docetaxel and paclitaxel induce cardiotoxicity in 2.3% to 8% of patients. They are mainly used in the treatment of patients with breast, lung or ovarian cancer.

What are the most toxic chemotherapy drugs?

Direct pairwise meta-analysis results also revealed that the gemcitabine + carboplatin chemotherapy regimen was the most toxic regimen in hematologic for AOC patients among 8 chemotherapy regimens.

Is cisplatin a cardiotoxic?

Cisplatin-induced cardiotoxicity is rare, and the prevalence remains unknown. Jakubowski and Kemeny showed that cardiotoxicity occurs in 6% of the patients receiving cisplatin and 5-fluorouracil (5-FU) and in 1.6% of the patients receiving 5-FU alone.

Can chemo cause atrial fibrillation?

Arrhythmias were reported as a side effect of many chemotherapeutic drugs. Anthracyclines are associated with atrial fibrillation (AF) at a rate of 2–10%, but rarely with ventricular tachycardia (VT)/fibrillation.

Is carboplatin a cardiotoxic?

Patients treated with the first-line chemotherapy paclitaxel/carboplatin developed cardiotoxicity more frequently if they had a former history of cardiovascular diseases, and the statistical significance was registered at the first follow-up examination in stage III NSCLC patients (p = 0.037).

Is HERceptin a cardiotoxic?

Similarly, final analysis from HERceptin Adjuvant trial also reported much lower rate of cardiotoxicity with 7.25% incidence of secondary cardiac endpoint (class I or II toxicity as defined by New York Heart Association) in 2-year trastuzumab group and 4.4% in 1-year trastuzumab [16].

What is cardiotoxic chemotherapy?

Cardiotoxicity, or medication-induced damage to the heart muscle—e.g., heart failure (HF), structural damage, and hypertension)— is a known adverse effect of many conventional chemotherapeutic agents.

What is the chemo drug called Red Devil?

Can the red devil be defanged? Doxorubicin, an old chemotherapy drug that carries this unusual moniker because of its distinctive hue and fearsome toxicity, remains a key treatment for many cancer patients.

Is 5fu cardiotoxic?

5-fluorouracil (5-FU) is a fluoropyrimidine (FP) antimetabolite agent used in a variety of solid tumors treatment. A potential severe side effect of 5-FU is cardiotoxicity, which often presents with chest pain related to coronary vasospasm.

What does cardiotoxic mean?

Cancer drugs and treatments can cause direct damage to the heart. This is known as cardiotoxicity.