Which blood component is associated with von Willebrand disease?
Platelet-type von Willebrand disease (PT-VWD), also known as pseudo-von Willebrand disease, is an extremely rare genetic disorder characterized by prolonged bleeding time. Unlike VWD, the underlying defect affects platelets, which have an unusually high binding affinity to VWF.
Can von Willebrand disease cause headaches?
VWD is an independent risk factor for headaches. (OR 7.11, 95% CI 3.10 – 16.34, p = 0.001). Our analysis suggests that there is a very strong association of Von Wille brand disease with migraines.
What is acquired von Willebrand syndrome?
Acquired von Willebrand syndrome (AVWS) is a rare bleeding disorder that is characterized by structural or functional alterations in von Willebrand factor (VWF) caused by a range of lymphoproliferative, myeloproliferative, cardiovascular, autoimmune, and other disorders.
How I treat acquired von Willebrand syndrome?
Because of the heterogeneous mechanisms of AVWS, more than one therapeutic approach is often required to treat acute bleeds and for prophylaxis during invasive procedures; the treatment options include, but are not limited to, desmopressin, VWF-containing concentrates, intravenous immunoglobulin, plasmapheresis or …
Can von Willebrand disease cause joint pain?
For example, patients with Type 3 von Willebrand disease may experience bleeding into the joints or joint spaces (also known as a hemarthrosis) because they also have a low factor VIII level. Symptoms of joint bleeding include joint pain and swelling.
Can von Willebrand disease cause low platelet count?
Von Willebrand disease (VWD) is a hereditary deficiency of von Willebrand factor (VWF), which causes platelet dysfunction. Bleeding tendency is usually mild. Screening tests show a normal platelet count and, possibly, a slightly prolonged partial thromboplastin time (PTT).
Which of the following lab values is most commonly found in VWD?
Prothrombin Time (PT) Test If the level of any one of these factors is too low, it will take longer than normal for the blood to clot. The results of this test will be normal among most people with VWD.