Which antimalarial is safe in G6PD deficiency?

Which antimalarial is safe in G6PD deficiency?

Majority of the cases in literature incriminate primaquine for haemolysis in patients with malaria. However, primaquine, has been safely given to individuals with the G6PD A- variant as long as a low dose is used (15 mg/day or 45 mg once or twice weekly) under close supervision of blood counts.

WHO recommended malaria prophylaxis?

Table 1

Drug Dose (adult) End of prophylaxis (after exposure)
Mefloquine 250 mg 4 weeks
Doxycycline 100 mg 4 weeks
Primaquine * G6PD testing is mandatory before its use 30 mg (base) [usually =2 tabs] 3–7 days
Chloroquine 300 mg (base) =500 mg salt 4 weeks

Is artesunate safe in G6PD deficiency?

Conclusions. Chlorproguanil-dapsone+artesunate in Rwanda had a poor safety profile in G6PD deficient individuals most likely as a result of dapsone induced haemolysis.

What medications should be avoided in G6PD deficiency?

The following is a partial list of medications and chemicals that individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency should avoid:

  • Acetanilid.
  • Furazolidone.
  • Isobutyl nitrite.
  • Nalidixic acid.
  • Naphthalene.
  • Niridazole.
  • Sulfa drugs.

What is G6PD test for malaria?

G6PD deficiency causes problems primarily when the deficiency is complicated by the treatment of malaria. Treatment can cause (severe) hemolysis in G6PD-deficient patients. Therefore, patients should be screened for G6PD deficiency before treatment with these potential hemolytic agents.

Does malaria prophylaxis prevent malaria?

Malaria prophylaxis is the preventive treatment of malaria. For pregnant women who are living in malaria endemic areas, routine malaria chemoprevention is recommended. It improves anemia and parasite level in the blood for the pregnant women and the birthweight in their infants.

WHO guideline for artesunate?

Treat adults and children with severe malaria with intravenous or intramuscular artesunate for at least 24 hours (including infants, pregnant women in all trimesters, and lactating women).

When do you give artesunate in malaria?

Parenteral artesunate: The recommended treatment for severe malaria. Dosing: Artesunate 2.4 mg/kg body weight (bw) administered intravenously (IV) or intramuscularly (IM) at the time of admission (time=0), then at 12h and 24 h, then once a day until the patient is able to take oral medication.

Does G6PD protect against malaria?

As G6PD deficiency leads to increased oxidative stress in red blood cells, this may in turn have a negative influence on the parasite. As such, individuals who possess this mutation have some protection against malaria.

Why is G6PD tested for malaria?

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