What type of drug is primaquine?

What type of drug is primaquine?

Primaquine is used to treat malaria and prevents it from coming back after treatment (relapse). Primaquine belongs to a group of medicines, called antiprotozoals. It works by treating malaria, a red blood cell infection transmitted by the bite of a mosquito.

What is the purpose of primaquine?

Primaquine is used alone or with another medication to treat malaria (a serious infection that is spread by mosquitoes in certain parts of the world and can cause death) and to prevent the disease from coming back in people that are infected with malaria. Primaquine is in a class of medications called antimalarials.

What is the difference between primaquine and chloroquine?

Chloroquine is a highly effective schizontocide, while primaquine has weaker asexual-stage activity (3) but is the only generally available drug with hypnozoitocidal properties, i.e., it kills dormant liver stage parasites and prevents relapse (radical cure) (1).

Why primaquine is used with chloroquine?

Primaquine is used after other medications (such as chloroquine) have killed the malaria parasites living inside red blood cells. Primaquine then kills the malaria parasites living in other body tissues. This prevents the return of the infection. Both drugs are needed for a complete cure.

Why is primaquine contraindicated in G6PD deficiency?

Primaquine should not be administered to anyone with G6PD deficiency because a severe reaction can occur, resulting in hemolytic anemia.

How effective is primaquine?

Efficacy. The hypnozoitocidal activity of primaquine is predominantly a function of total dose administered; 3.5 mg base/kg (adult dose ~15 mg/day for 14 days) prevents >90% of long latency P.

Is primaquine an antibiotic?

Primaquine is an antibiotic used to treat different types of infections. It can be given in combination with clindamycin (Dalacin® C) for the treatment of Pneumocystis carinii pneumonia (PCP).

Who should not take primaquine?

Who should not take primaquine? Pregnant women and people with glucose-6-phosphate dehydrogenase (or G6PD) deficiency should not take primaquine.

What is the mechanism of action of primaquine?

Primaquine. Although its mechanism of action is unclear, primaquine bind to and alter the properties of protozoal DNA. This agent eliminates tissue (exo-erythrocytic) malarial infection, preventing the development of the erythrocytic forms of the parasite which are responsible for relapses in Plasmodium vivax and ovale malaria.

Is primaquine glyco-conjugate a potential tissue schizontocidal antimalarial agent?

Synthesis of primaquine glyco-conjugates as potential tissue schizontocidal antimalarial agents Primaquine (PQ) is the only drug used to prevent relapse of malaria due to P. vivax and P. ovale, by eradicating the dormant liver form of the parasite (hypnozoites).

What is Primaquine Phosphate?

Primaquine Phosphate is the phosphate salt form of primaquine, a synthetic, 8-aminoquinoline derivative with antimalarial properties. Although its mechanism of action is unclear, primaquine bind to and alter the properties of protozoal DNA.

How does primprimaquine work?

Primaquine is in a class of medications called antimalarials. It works by killing the organisms that cause malaria. How should this medicine be used? Primaquine comes as a tablet to take by mouth.

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