What is the origin of neural crest cells?
Neural crest cells originate in the ectoderm at the margins of the neural tube and, after a phase of epithelial-mesenchymal transition and extensive migration, settle down in different parts of the body to contribute to the formation of a plethora of different tissues and organs.
How do neural crest cells migrate from the neural tube?
After neural tube closure, neural crest cells depart from the dorsal CNS via an epithelial to mesenchymal transition (EMT), forming a migratory mesenchymal cell type that migrates extensive to diverse locations in the embryo. This in turn leads to the EMT process that produces this migratory cell population.
Do neural crest cells differentiate before they migrate?
Neural crest cells (NCC) are multipotent cells induced at the border of the neural plate that subsequently migrate throughout the embryo and later differentiate into multiple cell types contributing to most of the peripheral nervous system and the cranio-facial cartilage and bones, as well as pigment and endocrine …
What do neural crest cells differentiate into?
The cranial (cephalic) neural crest, whose cells migrate dorsolaterally to produce the craniofacial mesenchyme that differentiates into the cartilage, bone, cranial neurons, glia, and connective tissues of the face.
What is neural crest migration?
Neural crest cells are a transient embryonic cell population that migrate collectively to various locations throughout the embryo to contribute a number of cell types to several organs.
How are neural crest cells specified?
After gastrulation, neural crest cells are specified at the border of the neural plate and the non-neural ectoderm. The emergence of neural crest was important in vertebrate evolution because many of its structural derivatives are defining features of the vertebrate clade.
What is neural tube and neural crest?
The neurula-stage of development occurs when the neural plate folds and transforms into the neural tube, the structure that will eventually develop into the central nervous system. The neural crest arises at two junctions, one on each side of the midline of the neural plate, between neural and non-neural ectoderm.
What is the neural crest?
neural crest, group of embryonic cells that are pinched off during the formation of the neural tube (the precursor of the spinal cord) but that do not remain as a part of the central nervous system.
What is a neural crest?
Neural crest cells (NCCs) are a multipotent and migratory cell population in the developing embryo that contribute to the formation of a wide range of tissues. Defects in the development, differentiation and migration of NCCs give rise to a class of syndromes and diseases that are known as neurocristopathies.
What is the neural crest and what is its importance?
Early in the process of development, vertebrate embryos develop a fold on the neural plate where the neural and epidermal ectoderms meet, called the neural crest. The neural crest produces neural crest cells (NCCs), which become multiple different cell types and contribute to tissues and organs as an embryo develops.