What is Ptprc gene?
PTPRC (Protein Tyrosine Phosphatase Receptor Type C) is a Protein Coding gene. Diseases associated with PTPRC include Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Positive and Hepatitis C Virus. An important paralog of this gene is PTPRD.
What Ly5 2?
The Ptprcb (Ly5. 2) allele is expressed by the C3H, DBA/2, and AKR strains as well as the C57BL/6. Taconic Biosciences offers a B6. SJL-Ptprca/BoAiTac congenic mouse which carries the SJL allele for Ptprca. The origin of the model states that Ly5.
What is the difference between CD45RA and CD45RO?
CD45RA is the long isoform of CD45 and is expressed on naive T cells. CD45RO is the shorter isoform, and is expressed on T cells that have encountered antigens.
What are CD5 cells?
CD5 is a cluster of differentiation expressed on the surface of T cells (various species) and in a subset of murine B cells known as B-1a. CD5 was used as a T-cell marker until monoclonal antibodies against CD3 were developed. In humans, the gene is located on the long arm of chromosome 11.
What is the difference between CD45 1 and CD45 2?
Different isoforms of CD45 have been identified in mice; the common form is CD45. 2, which is expressed by C57BL/6 mice, and is encoded by the Ptprc b allele. However, an additional allelic variant, Ptprc a, which translates to the CD45. 1 form of the surface protein, has been identified in the SJL mouse strain.
What is CD45 1 a marker for?
Allelic variants of the pan-haematopoietic cell marker CD45, identified as CD45. 1 and CD45. 2, have been established as a marker system to track haematopoietic cells following congenic mouse bone marrow transplants.
Is granzyme B cytokine?
Granzyme B has shown to be involved in inducing inflammation by stimulating cytokine release and is also involved in extracellular matrix remodelling.
What are CD45RA cells?
CD45RA T cells have “naive” characteristics of unresponsiveness to recall antigens and prominence in cord blood, while CD45RO T cells are considered “memory” T cells because they proliferate to recall antigens and increase following PHA activation of cord blood.
What is the function of CD52?
CD52 is a peptide of 12 amino acids, anchored to glycosylphosphatidylinositol (GPI). Since it is highly negatively charged and present on sperm cells and lymphocytes, it has been conjectured that its function is anti-adhesion, allowing cells to freely move around.
What are CD45 cells?
CD45 (lymphocyte common antigen) is a receptor-linked protein tyrosine phosphatase that is expressed on all leucocytes, and which plays a crucial role in the function of these cells. These CD45-associated molecules may play an important role in regulating CD45 tyrosine phosphatase activity and function.
What are CD45 2 cells?
CD45. 2 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes.
What does PTPRC stand for?
The PTPRC (formerly CD45) classical protein tyrosine phosphatase, expressed in all nucleated cells of hematopoietic origin, first alerted the attention of immunologists because of its great abundance (5–10% of membrane proteins).
Is rheumatoid arthritis risk allele PTPRC related to anti–tumor necrosis factor α therapy?
Rheumatoid Arthritis Risk Allele PTPRC Is Also Associated With Response to Anti–Tumor Necrosis Factor α Therapy NCBI Skip to main content Skip to navigation Resources How To About NCBI Accesskeys My NCBISign in to NCBISign Out PMC US National Library of Medicine National Institutes of Health
Why does ptptprc exist in several isoforms?
PTPRC exists in several isoforms due to alternative splicing in its extracellular domain, and which are widely used in identification and selection of immune cells.
Does the major allele predict the likelihood of a good response?
The major allele (G allele), which is a known predictor of RA risk, is the same allele that was found to be a predictor of favorable response; in the presence of the major allele, the OR for the likelihood of a EULAR good response was 0.59 and 0.55 in univariate and multivariate models, respectively.