What is LP-X?

What is LP-X?

Lp-X, an abnormal form of LDL, has a vesicular structure that appears in rouleaux formation under the electron microscope. 63. It is virtually specific for cholestasis and familial lecithin:cholesterol acyltransferase (LCAT) deficiency.

What is LpX lipoprotein?

Lipoprotein X (LpX) is an abnormal lipoprotein fraction, which can be detected in patients with severe hypercholesterolaemia and cholestatic liver disease. LpX is composed largely of phospholipid and free cholesterol, with small amounts of triglyceride, cholesteryl ester and protein.

What is LCAT biochemistry?

The LCAT gene provides instructions for making an enzyme called lecithin-cholesterol acyltransferase (LCAT). This enzyme plays a role in removing cholesterol from the blood and tissues. The LCAT enzyme helps transport cholesterol out of the blood and tissues by a process called cholesterol esterification.

Is chylomicron a lipoprotein?

Chylomicrons are large triglyceride-rich lipoproteins produced in enterocytes from dietary lipids—namely, fatty acids, and cholesterol. Chylomicrons are composed of a main central lipid core that consists primarily of triglycerides, however like other lipoproteins, they carry esterified cholesterol and phospholipids.

What is the meaning of LP?

long playing
long playing; long play: a full-length music album, typically comprised of ten to twelve songs: called LP as an evolution of the traditional long-playing record, albums in other formats are not known by the underlying expanded form, and identified only by the abbreviation.

What is Tangiers disease?

Tangier disease is an inherited disorder characterized by significantly reduced levels of high-density lipoprotein (HDL) in the blood. HDL transports cholesterol and certain fats called phospholipids from the body’s tissues to the liver, where they are removed from the blood.

Which lipoprotein has highest cholesterol content?

LDL carries the majority of the cholesterol that is in the circulation. The predominant apolipoprotein is B-100 and each LDL particle contains one Apo B-100 molecule.

Is LCAT a protein?

The enzyme is bound to high-density lipoproteins (HDLs) (alpha-LCAT) and LDLs (beta-LCAT) in the blood plasma….Lecithin–cholesterol acyltransferase.

RefSeq (mRNA) NM_000229 NM_008490
RefSeq (protein) NP_000220 NP_032516
Location (UCSC) Chr 16: 67.94 – 67.94 Mb Chr 8: 105.94 – 105.94 Mb
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Where do chylomicrons go?

Nearly all dietary lipid is transported in chylomicrons from the gut to the blood through the lymphatic system by entering specialized lymphatic vessels, referred to as lacteals, in the villi of the intestine (Fig. 1).

What’s HDL level?

HDL (high-density lipoprotein), or “good” cholesterol, absorbs cholesterol and carries it back to the liver. The liver then flushes it from the body. High levels of HDL cholesterol can lower your risk for heart disease and stroke.

Can cholestasis be cured?

Cholestasis can occur at any age, and in both males and females. Recovery depends on how severe the case was before it was first diagnosed. Another factor is the underlying cause of the disease and how well it can be managed. For example, gallstones can be removed, which essentially cures the disease.

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