What is germinal center lymphoma?
Germinal center‐derived lymphomas are markedly heterogeneous, as befitting a tissue of origin that naturally undergoes rapid clonal diversification. They are among tumors with the highest burden of somatic mutations, and physically manifest in very diverse manners.
What are Germinal Centres?
The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid tissues, producing long-lived antibody secreting plasma cells and memory B cells, which can provide protection against reinfection.
What is GCB Dlbcl?
Germinal Center B-Cell like (GCB) DLBCLs appear to arise from normal germinal center B cells, while Activated B-cell like (ABC) DLBCLs are thought to arise from postgerminal center B cells that are arrested during plasmacytic differentiation.
What is the germinal center of a lymphoid organ?
Germinal centers or germinal centres (GCs) are transiently formed structures within B cell zone (follicles) in secondary lymphoid organs – lymph nodes, ileal Peyer’s patches, and the spleen – where mature B cells are activated, proliferate, differentiate, and mutate their antibody genes (through somatic hypermutation …
What is non germinal center lymphoma?
Non-germinal center (non-GC) phenotype is an adverse prognostic factor in chemotherapy (CT)-treated diffuse large B-cell lymphoma (DLBCL) patients.
How are germinal centres formed?
Germinal centers develop in the B cell follicles of secondary lymphoid tissues during T cell-dependent (TD) antibody responses. The B cells that give rise to germinal centers initially have to be activated outside follicles, in the T cell-rich zones in association with interdigitating cells and T cell help.
What is germinal center reaction?
The germinal center (GC) reaction is the basis of T-dependent humoral immunity against foreign pathogens and the ultimate expression of the adaptive immune response. 1-3 He named these structures with strong cell division germinal centers (GCs) under the assumption that they were the main origin of lymphocytes.
What is GCB type lymphoma?
Background. Diffuse large B cell lymphoma (DLBCL) is divided into Germinal center B-cell like (GCB) subtype and non-GCB by the Hans algorithm and non-GCB is known to be associated with unfavorable prognosis.
What causes germinal center formation?
Abstract. During a T-dependent immune response, activated B cells enter structures called germinal centers (GCs) in the follicles of secondary lymphoid organs. GC B cells proliferate and undergo diversification of their immunoglobulin (Ig) through somatic hypermutation and class-switch recombination.
What is non-germinal center type?