What is Dioleoyl phosphatidylcholine?

What is Dioleoyl phosphatidylcholine?

Description. 1,2-dioleoyl-sn-glycero-3-phosphocholine is a phosphatidylcholine 36:2 in which the phosphatidyl acyl groups at positions 1 and 2 are both oleoyl. It is a 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine betaine and a 1,2-di-octadecenoyl-sn-glycero-3-phosphocholine. It derives from an oleic acid.

What is phosphatidylcholine used for?

Because the body uses phosphatidylcholine to make a brain chemical called acetylcholine, there is some interest in using it for treating “brain-centered” conditions such as memory loss, Alzheimer’s disease, anxiety, manic-depressive disorders, and a movement disorder called tardive dyskinesia.

Is phosphatidylcholine good for your liver?

4) Liver Health Very low levels of phosphatidylcholine can cause liver damage and even death in mice. An animal study showed that phosphatidylcholine can promote liver regeneration [43, 8].

What is Distearoylphosphatidylcholine made from?

It is a natural constituent of cell membranes, eg. soybean phosphatidylcholines are mostly different 18-carbon phosphatidylcholines (including minority of saturated DSPC), and their hydrogenation results in 85% DSPC….Distearoylphosphatidylcholine.

ChemSpider 85004
ECHA InfoCard 100.011.309
EC Number 212-440-2

What is DOPC bilayer?

The Structure of a Fluid DOPC Bilayer A representation of the liquid-crystallographic structure of an Lα-phase dioleoylphosphatidylcholine (DOPC) bilayer (8) is shown in Figure 2A. The areas under the peaks are equal to the number of structural groups per lipid molecule (e.g. two methyls, 28 methylenes, one phosphate).

What is DOPS lipid?

1,2-dioleoyl-sn-glycero-3-phospho-L-serine (sodium salt) DOPS is an excellent substitute for the naturally occurring Brain PS. It has similar physical properties and is more stable to oxidation. DOPS has been used, along with DOPC and DOPE, in lipid mixtures to mimic platelet membranes for coagulation studies.

Is phosphatidylcholine good for brain?

It can help boost cognitive function According to a 1995 study on mice with dementia , PC supplementation can increase the neurotransmitter acetylcholine in the brain. It may also improve memory.

Can phosphatidylcholine cause depression?

Plasma phosphatidylcholine and sphingomyelin concentrations are associated with depression and anxiety symptoms in a Dutch family-based lipidomics study. J Psychiatr Res.

Is it safe to take phosphatidylcholine?

When taken by mouth: Phosphatidylcholine is POSSIBLY SAFE when taken by mouth, in a dose up to 30 grams per day for 6 weeks, or up to 6 grams per day for 2 years. When phosphatidylcholine is taken by mouth, it can sometimes cause excessive sweating, stomach upset, and diarrhea.

Can you take too much phosphatidylcholine?

Oral PC may cause excessive sweating, and taking more than 30 grams daily may cause: diarrhea. nausea. vomiting.

Is DSPC toxic?

Given the use of air and vehicle controls in a range of inhalation toxicology studies as well as negative genotoxicity and also reproductive toxicity results, it is thought that the use of DSPC is shown to be safe for pulmonary administration.

Is DSPC safe?

In the inhalation field, lipids such as egg phosphatidylcholine (PC), 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and dipalmitoylphosphatidylcholine (DPPC), are considered to be generally recognized as safe (GRAS), comprising materials that are endogenous to the lungs and locally present in large quantities.

What is dipalmitoylphosphatidylcholine?

Dipalmitoylphosphatidylcholine (DPPtdCho) is a phospholipid (and a lecithin) consisting of two palmitic acids attached of a phosphatidylcholine head-group and is the major constituent of many pulmonary surfactants.

How is dioleoyl-sn-glycero-3-phosphocholine (DOPC) dissolved?

DOPC is dissolved in sterile tert -butanol to produce a 20-mg/ml stock solution. tert -Butanol is the organic solvent of choice for human delivery, as much of the solvent can be removed by evaporation and it solubilizes liposomes effectively. DOPC is then added to a sterile glass vial. Fig. 2. 1,2-Dioleoyl- sn -glycero-3-phosphocholine (DOPC).

What is the most common type of phospholipid?

Among the phospholipids, the most prevalent one is phosphatidylcholine (PC, or lecithin) (70–85%), which in turn is the basis of a pool of similar diacylphophatidylcholines of which 50% is dipalmitoylphosphatidylcholine or DPPC.

Where does the synthesis of phospholipids take place in pulmonary surfactant?

The synthesis of the phospholipids contained in pulmonary surfactant takes place in the endoplasmic reticulum of type II pneumocytes. Pulmonary surfactant has both protein and lipid components.

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