What is antifungal agent Slideshare?
Antifungal agents. Yeasts • Fungi may be classified as Moulds • Yeasts: Blastomyces, candida, histoplasma, coccidioides, cryptococcus. • Moulds: Aspergillus spp. Dermatophytes, mucor Superficial mycosis • Clinically classified as: Deep (systemic) mycosis.
Which antifungal drug is fungicidal?
These include ketoconazole, itraconazole, fluconazole, fosfluconazole, voriconazole, posaconazole, and isavuconazole. Examples of non-azole systemic antifungals include griseofulvin and terbinafine.
How are antifungal agents classified?
The four main classes of antifungal drugs are the polyenes, azoles, allylamines and echinocandins.
Which is an example of an antifungal agent?
The clinically useful imidazoles are clotrimazole, miconazole, and ketoconazole. Two important triazoles are itraconazole and fluconazole.
What are azoles?
Azoles are synthetic antifungals with broad-spectrum fungistatic activity against yeasts and fungi, including candidal species. By blocking fungal cytochrome P450-dependent enzymes, azoles disrupt the synthesis of ergosterol, which is the principal sterol in fungal cell membranes.
What are the three classes of antifungals?
Antifungals can be grouped into three classes based on their site of action: azoles, which inhibit the synthesis of ergosterol (the main fungal sterol); polyenes, which interact with fungal membrane sterols physicochemically; and 5-fluorocytosine, which inhibits macromolecular synthesis.
Is voriconazole a fungicidal?
Voriconazole has shown activity against Aspergillus spp. in vitro (8, 12–16). Growth-inhibition studies have shown voriconazole to be fungicidal against the various Aspergillus spp. Voriconazole and itraconazole have similar minimum inhibitory concentrations (MICs) when tested against Aspergillus spp.
Is clotrimazole an azole?
The azole antifungal agents in clinical use contain either two or three nitrogens in the azole ring and are thereby classified as imidazoles (e.g., ketoconazole and miconazole, clotrimazole) or triazoles (e.g., itraconazole and fluconazole), respectively.