What is a QTL marker?
From Wikipedia, the free encyclopedia. A quantitative trait locus (QTL) is a locus (section of DNA) that correlates with variation of a quantitative trait in the phenotype of a population of organisms. QTLs are mapped by identifying which molecular markers (such as SNPs or AFLPs) correlate with an observed trait.
What is meta QTL analysis?
Meta-QTL analysis is a useful approach for dissecting the genetic basis of complex traits, providing broader allelic coverage and higher mapping resolution for the identification of putative molecular markers to be used in marker-assisted selection.
What is a marker analysis?
Marker Analysis is a technique where the gene mutation is analyzed using a genetic marker instead of directly analyzing the gene itself. A genetic marker is a short sequence of DNA associated with a particular gene or trait with a known location on a chromosome.
What is the difference between gene and QTL?
A QTL is a genetic locus, the alleles of which affect this variation. Generally, quantitative traits are multifactorial and are influenced by several polymorphic genes and environmental conditions, so one or many QTLs can influence a trait or a phenotype.
What is the difference between GWAS and QTL?
The basic difference between GWAS and QTL mapping is that GWAS studies the association between alleles and and a binary trait, such as being a sufferer of a disease, while QTL analysis deals with the contribution of a locus to variation in continuous trait like height.
What is methylation quantitative trait loci?
Methylation quantitative trait loci (mQTLs) are the genetic variants that may affect the DNA methylation patterns of CpG sites. However, their roles in influencing the disturbances of smoking-related epigenetic changes have not been well established.
Why is marker analysis used?
Genetic Marker Genetic markers can help link an inherited disease with the responsible gene. DNA segments close to each other on a chromosome tend to be inherited together. Genetic markers are used to track the inheritance of a nearby gene that has not yet been identified, but whose approximate location is known.
What are the disadvantages of single marker analysis?
The disadvantages and limitations of single marker analysis are based on Collard et al. The further a marker is from a QTL, the more difficult the QTL is to detect, due to recombination between the marker and QTL. QTL effects may be underestimated due to recombination between the marker and QTL.
What is interval mapping?
Interval mapping is an extension of the individual marker analysis so that two markers are analyzed at a time. With interval mapping, we use two markers to determine an interval, within which a putative QTL position is proposed.
What are the different types of markers used in QTL mapping?
Several types of markers are used, including single nucleotide polymorphisms (SNPs), simple sequence repeats (SSRs, or microsatellites), restriction fragment length polymorphisms (RFLPs), and transposable element positions (Casa et al., 2000; Vignal et al., 2002; Gupta & Rustgi, 2004; Henry, 2006).