What causes RS3PE syndrome?
Although the cause of RS3PE is unknown, the following may contribute to the disease: Elevated levels of vascular endothelial growth factor and matrix metalloproteinase 3. Paraneoplastic syndrome. HLA-B7, HLA-CW7, and HLA-DQW.
What is RS3PE syndrome?
Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare syndrome characterized by “remitting,” “seronegative” (namely rheumatoid factor-negative), and “symmetrical” synovitis with pitting edema on the dorsum of the hands and feet.
Is RS3PE an autoimmune disease?
Although RS3PE is known to be a disease of the elderly population, it is also seen in young age groups, but it is extremely rare. Systemic vasculitis, autoimmune diseases, and malignancy accompany in 30% of RS3PE patients [9,10].
What does r3pe mean?
Abstract. Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is characterized by symmetrical synovitis and swelling of both the upper and lower extremities. The anatomical determinant of RS3PE is predominantly extensor tenosynovitis as revealed by magnetic resonance imaging (MRI).
Is palindromic rheumatism curable?
There is no cure for palindromic rheumatism at the moment, but certain treatments and lifestyle changes can improve people’s symptoms, reduce the severity of attacks, and improve quality of life.
What diseases can mimic PMR?
What diseases mimic PMR?
- rheumatoid arthritis (RA)
- tendonitis or bursitis.
- Lyme disease.
Can PMR be unilateral?
In most patients, symptoms appear first in the shoulder girdle. In the remainder, the hip or neck are involved at onset. At presentation, symptoms may be unilateral but they usually become bilateral within a few weeks. The symptoms include pain and stiffness of the shoulder and hip girdle.
Is palindromic rheumatism rare?
Palindromic rheumatism (PR) is a rare type of inflammatory arthritis. Between attacks of joint pain and swelling, the symptoms disappear, and the affected joints go back to normal with no lasting damage.
Can palindromic arthritis go away?
Unlike other forms of arthritis, the symptoms of palindromic arthritis come and go without leaving permanent damage in the joints.
Can polymyalgia affect your legs?
The most common symptoms of PMR are severe pain and stiffness in the muscles of the shoulders, neck, lower back, buttocks, and thighs. The muscles of the upper arms may also be affected but it is unusual for the muscles in the forearms, hands, legs and feet to be affected.
What does polymyalgia pain feel like?
The signs and symptoms of polymyalgia rheumatica usually occur on both sides of the body and might include: Aches or pain in your shoulders. Aches or pain in your neck, upper arms, buttocks, hips or thighs. Stiffness in affected areas, particularly in the morning or after being inactive for a time.
Can PMR affect only one side?
Physical Symptoms of PMR Symmetrical joint pain is commonly seen in PMR affecting both the right and left sides (for example, both shoulders or both hips).
What is RS3PE (Remitting seronegative symmetrical synovitis with pitting edema)?
GM, June, 2013 Remitting Seronegative Symmetrical Synovitis with Pitting Edema(RS3PE), first described in 1985 by McCarty et al, is a rare syndrome that is a subset of the seronegative symmetrical polyarthritis of older people.1
What is the classic presentation of rheumatoid arthritis (RS3PE)?
Bilaterally, symmetrical presentation had been classically described, but now unilateral RS3PE is well-recognized.[3,4] Although the disease is more prevalent in the geriatric age group, a young case has also been reported. Female cases are in abundance to challenge the male predominance that was originally described.
Is RS3PE the same as giant cell arteritis?
However RS3PE has never been described in association with giant cell arteritis unlike PMR. In a 23 patient prospective study in 1999, it found that a subgroup (12%) of PMR patients had distal extremity swelling with pitting oedema of the hands which was consistent with RS3PE.8 This study from Italy shows similarities between RS3PE and PMR.