What antibiotics treat streptococcal toxic shock syndrome?
The usually prescribed antibiotics are nafcillin, oxacillin, and first generation cephalosporin. Nafcillin or oxacillin (2 g q4h) is generally recommended. Vancomycin can be used in penicillin-allergic patients. These agents have been known to increase TSST-1 in culture possibly by cell lysis.
Who discovered streptococcal toxic shock syndrome?
In 1979, Dr. Schlievert accepted a faculty position at UCLA in the Microbiology and Immunology Department, where he discovered toxic shock syndrome (TSS) toxin-1, the principle cause of TSS, and demonstrated the main reason why tampons are associated with TSS.
How is streptococcal toxic shock syndrome contracted?
Disease occurs with entry of the bacterium through a compromised barrier (such as a skin injury) or through mucus membranes. The bacteria then spread to deep tissues and eventually to the bloodstream. The main sites of entry for streptococci leading to toxic shock syndrome include: Vagina.
Can STSS be cured?
Doctors treat STSS with antibiotics. People with STSS need care in a hospital. They often need fluids given through a vein and other treatments to help treat shock and organ failure. Many people with STSS also need surgery to remove infected tissue.
What is streptococcal sepsis?
Expand Section. Septicemia is an infection in the bloodstream (also called bacteremia) that may travel to different body organs. GBS septicemia is caused by the bacterium Streptococcus agalactiae, which is commonly called group B strep, or GBS.
Who named toxic shock syndrome?
Initial description. The term “toxic shock syndrome” was first used in 1978 by a Denver pediatrician, James K. Todd, to describe the staphylococcal illness in three boys and four girls aged 8–17 years.
What is the main cause of streptococcal toxic shock syndrome?
Streptococcal TSS is caused by an infection with Streptococcus pyogenes, also known as group A streptococcus (GAS), and is usually associated with skin infections, child birth, and surgeries. Infection occurs at a site of trauma or can follow viral infections (influenza or varicella).
What causes group A streptococcus?
How are Group A Streptococci Spread? These bacteria are spread by direct contact with discharges from the nose and throat of infected people or by contact with infected wounds or sores on the skin.
Is Period blood toxic?
They found that menstrual blood contains a toxin so potent that 0.05 to 0.2 cc. of whole menstrual discharge would kill 1% to 24-day-old rats within 18 to 48 hours after a single subcutaneous injection. After this material was centrifuged, a lethal dose of toxin was contained in 0.1 to 2 cc.