Is Henoch-Schönlein purpura serious?
The most serious complication of Henoch-Schonlein purpura is kidney damage. This risk is greater in adults than in children. Occasionally the damage is severe enough that dialysis or a kidney transplant is needed. Bowel obstruction.
Does HSP cause thrombocytopenia?
We present a patient with a severe form of HSP nephritis who had unusual laboratory findings of a low level of C3, mild leukopenia and thrombocytopenia. These findings may further support the importance of complement activation in the pathogenesis of HSP.
What is the pathophysiology of HSP?
The pathophysiology of Henoch-Schönlein purpura is not fully understood; however, IgA plays a significant role. IgA-antibody immune complexes caused by antigenic exposure from an infection or medication deposit in the small vessels (usually capillaries) of the skin, joints, kidneys, and gastrointestinal tract.
Is Henoch Schonlein Purpura an autoimmune disease?
HSP is an autoimmune disorder. This is when the body’s immune system attacks the body’s own cells and organs. With HSP, this immune response may be caused by an upper respiratory tract infection. Other immune triggers may include an allergic reaction, medicine, injury, or being out in cold weather.
How is Henoch Schonlein purpura diagnosed?
HSP is usually diagnosed based on the typical skin, joint, and kidney findings.
- Throat culture, urinalysis, and blood tests for inflammation and kidney function are used to suggest the diagnosis.
- A biopsy of the skin, and less commonly kidneys, can be used to demonstrate vasculitis.
Can adults get Henoch-Schönlein purpura?
Although HSP can affect people at any age, most cases occur in children between the ages of 2 and 11. It is more common in boys than girls. Adults with HSP are more likely to have more severe disease compared to children.
Can adults get Henoch Schonlein Purpura?
Is HSP permanent?
The majority of children with HSP experience joint pains. Children typically only have a few affected joints—hips, knees, and ankles. While the joints may swell for 1-3 days, there is no permanent damage.
Can adults get Henoch-Schonlein purpura?