Is cefazolin weight based dosing?
2. In adult patients, cefazolin (2 g if <120 kg, 3 g if ≥120 kg) and vancomycin (1 g if <80 kg, 1.5 g if ≥80 kg) dosing is based on weight. Adult patients <50 kg should refer to Patients <50 kg (Adult and Pediatric) Dosing recommendations for dosing.
When do you take 3 grams of cefazolin?
Three grams of parenteral cefazolin was given 30-60 minutes before skin incision.
Is Ancef weight based?
Currently there are no guidelines in the dosing of cefazolin for the obese population. Standard dosing of cefazolin 2 grams for patients <120 kg and 3 grams for patients >120 kg is used as the dose for surgical prophylaxis. This makes no provisions for weight based dosing.
Why is cefazolin used for surgical prophylaxis?
Cefazolin is the most commonly used antibiotic for prophylaxis. It offers the advantages of a moderately long half-life, activity against most staphylococci and streptococci (in addition to some gram-negative aerobic organisms), and low cost.
How much cefazolin should I take?
For mild infections, 250 to 500 mg IV or IM every 8 hours. For moderate to severe infections, 500 to 1,000 mg IV or IM every 6 to 8 hours. Usual maximum dose is 6 g/day.
How often do you Redose clindamycin?
Redosing of antimicrobials is recommended to occur at intervals of 1-2 times the half-life of the drug. Redosing intervals should be measured from the time of administration of the preoperative dose, not from the beginning of the procedure.
How do you give cefazolin IV?
Intravenous Injection: Administer solution directly into vein or through tubing. Dilute the reconstituted 500 mg, 1 g or 2g of Cefazolin-AFT in a minimum of 10 mL of Sterile Water for Injection. Inject solution slowly over a period of 3 to 5 minutes. Do not inject in less than 3 minutes.
Is cefazolin renally dosed?
Renal Dosing 500mg – 1.5g q8h.
Is clindamycin weight based dosing?
For treatment of bacterial infections: Adults—150 to 300 milligrams (mg) every 6 hours. For more severe infections, 300 to 450 mg every 6 hours. Children weighing 10 kilograms (kg) or more—Dose is based on body weight and must be determined by your doctor.
How often can you give cefazolin?
It is usually given every 6, 8, or 12 hours. The length of your treatment depends on the type of infection you have and how your body responds to the medication. You may receive cefazolin injection in a hospital or you may administer the medication at home.
What is the recommended dose of cefazolin for surgery?
Background Most surgical prophylaxis guidelines recommend a 3-g cefazolin intravenous dose in patients weighing ≥ 120 kg. However, this recommendation is primarily based on pharmacokinetic studies rather than robust clinical evidence.
Can cefazolin be used to prevent surgical site infection after obesity surgery?
Background: Cefazolin is used commonly to prevent surgical site infection (SSI) after operations on patients with morbid obesity (MO), but specific dosing guidelines are lacking.
Does cefazolin use increase SSI prevalence in non-obese patients?
While no statistically significant difference in SSI prevalence was observed in non-obese and obese patients, or those who weighed above and below 120 kg, who received a 2-g prophylactic cefazolin dose, trends toward an increase were evident.
Should weight-based dosing recommendations for antibiotic prophylaxis in obese patients be revised?
From an ASP point of view, antibiotic dosing recommendations should be reviewed and revised on the basis of PK principles that indicate that weight-based dosing has no basis for pre-operative prophylaxis in obese patients. Keywords: cefazolin; obesity dosing; weight-based dosing.