How long is amikacin good for?

How long is amikacin good for?

Amikacin injection is used to treat serious bacterial infections in many different parts of the body. This medicine is for short-term use only (7 to 10 days). Amikacin belongs to the class of medicines known as aminoglycoside antibiotics. It works by killing bacteria or preventing their growth.

Does amikacin need to be refrigerated?

Amikacin Sulfate Injection USP is supplied as a clear colorless to light straw colored solution which requires no refrigeration. At times the solution may become a very pale yellow; this does not indicate a decrease in potency.

Should amikacin be diluted?

The solution for intravenous use is prepared by adding the contents of a 500 mg vial to 100 or 200 mL of sterile diluent such as 0.9% sodium chloride injection or 5% dextrose injection or any of the compatible solutions listed below. The solution is administered to adults over a 30 to 60 minute period.

Can amikacin be diluted in sterile water?

IM use or IV use after dilution. The solution for intravenous use is prepared by adding the desired dose to 100mL or 200mL of sterile diluent such as normal saline or 5% dextrose in water or any other compatible solution. The solution is administered to adults over a 30 to 60-minute period.

How effective is amikacin?

Clinical trials demonstrated that amikacin was effective in infections caused by gentamicin and/or tobramycin-resistant strains of Gram-negative organisms, particularly Proteus rettgeri, Providencia stuartii, Serratia marcescens, and Pseudomonas aeruginosa.

How do you store amikacin injection?

Amikacin injection should be stored at room temperature. The solution becomes light straw-colored during storage, but this does not indicate a loss of potency.

When should amikacin levels be drawn?

Both peak and trough concentrations should be monitored. The trough sample is drawn immediately prior to the next dose. Peak samples should be drawn 60 minutes after an IM injection, 30 minutes after the end of a 30-minute IV infusion, or immediately after a 60-minute IV infusion.

Which is better amikacin or gentamicin?

Gentamicin was more active than amikacin against most species of enterobacteria, Haemophilus influenzae and Staphylococcus aureus but amikacin was more active against a proportion of Klebsiella and Providencia isolates.

How long does it take for amikacin to work?

At the recommended dosage level, uncomplicated infections due to amikacin-sensitive organisms should respond in 24 to 48 hours. If definite clinical response does not occur within 3 to 5 days, therapy should be stopped and the antibiotic susceptibility pattern of the invading organism should be rechecked.

How many mg of amikacin are in a vial?

The 500 mg per 2 mL vial and the 1 gram per 4 mL vial, each mL contains: 250 mg Amikacin(as the sulfate), 0.66% Sodium Metabisulfite, 2.5% Sodium Citrate Dihydrate, Water for Injection qs, Air replaced with Nitrogen. pH is adjusted with Sulfuric Acid and/or if necessary Sodium Hydroxide. pH 3.5-5.5.

What is the pH of amikacin 500 mg?

The 500 mg per 2 mL vial and the 1 gram per 4 mL vial each contain, per mL, 250 mg amikacin, USP (as the sulfate), 2.5% sodium citrate dihydrate, 0.66% sodium metabisulfite, and water for injection, q.s. pH is adjusted with sulfuric acid and/or, if necessary, sodium hydroxide. The pH is 3.5 to 5.5.

What is the stability of amikacin sulfate IV?

Stability in IV Fluids: Amikacin sulfate is stable for 24 hours at room temperature at concentrations of 0.25 and 5.0 mg/mL in the following solutions: 5% Dextrose Injection. 5% Dextrose and 0.2% Sodium Chloride Injection. 5% Dextrose and 0.45% Sodium Chloride Injection. 0.9% Sodium Chloride Injection.

How fast is amikacin absorbed in the body?

Intramuscular Administration Amikacin is rapidly absorbed after intramuscular administration. In normal adult volunteers, average peak serum concentrations of about 12, 16, and 21 mcg/mL are obtained 1 hour after intramuscular administration of 250 mg (3.7 mg/kg), 375 mg (5 mg/kg), 500 mg (7.5 mg/kg), single doses, respectively.

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