How effective is gemcitabine and docetaxel?
In that study, the overall response to gemcitabine and docetaxel combination therapy was 18.4% and the median overall survival was 12.1 months. In the current study, which examined 218 Korean patients, the objective response rate was 15.6%, while the median overall survival was 10.3 months.
What is gemcitabine docetaxel?
Gemcitabine-docetaxel (G-D) combination is an effective chemotherapy for patients with advanced soft tissue and bone sarcoma, first developed with G administered on days 1 and 8, and D on day 8 every 21 days and later modified to be administered every 14 days in 2012. The 14-day regimen has become increasingly adopted.
What is leiomyosarcoma?
Leiomyosarcoma, or LMS, is a type of rare cancer that grows in the smooth muscles. The smooth muscles are in the hollow organs of the body, including the intestines, stomach, bladder, and blood vessels. In females, there is also smooth muscle in the uterus.
Where does uterine sarcoma spread to?
If uterine sarcoma spreads, it tends to first go to places near the uterus. It can spread to the cervix, vagina, ovaries, fallopian tubes, and lymph nodes. In later stages, as it grows, it can spread to the bladder, bowel, lungs, liver, or bone.
What is the most common side effect of docetaxel?
The most common adverse reactions across all TAXOTERE indications are infections, neutropenia, anemia, febrile neutropenia, hypersensitivity, thrombocytopenia, neuropathy, dysgeusia, dyspnea, constipation, anorexia, nail disorders, fluid retention, asthenia, pain, nausea, diarrhea, vomiting, mucositis, alopecia, skin …
What type of chemo is gemcitabine?
Gemcitabine is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. Gemcitabine is classified as an antimetabolite.
Can chemo cure sarcoma?
Depending on the type and stage of sarcoma, chemotherapy may be given as the main treatment or as an adjuvant (addition) to surgery. Different types of sarcoma respond better to chemo than others and also respond to different types of chemo.
How fast do uterine sarcomas grow?
It can grow fast and may even double in size in as little as four weeks. The treatment needs to be initiated as soon as possible after its diagnosis.
How aggressive is uterine sarcoma?
Uterine sarcomas are rare tumors that tend to behave more aggressively and that are associated with a poor prognosis. Diagnosis is usually made following surgical intervention, which often has been performed for benign reasons. The management of uterine sarcomas should employ an interdisciplinary approach.
How long does a person live with uterine sarcoma?
Endometrial stromal sarcoma*
| SEER Stage | 5-Year Relative Survival Rate |
|---|---|
| Localized | 99% |
| Regional | 92% |
| Distant | 76% |
| All SEER stages combined | 95% |
Is docetaxel a strong chemo?
Because the active ingredient, docetaxel, is a strong chemotherapy drug, it also has a long list of side effects. Most of them are typical for drugs in this class, such as nausea, vomiting and temporary alopecia (hair loss).
How long after docetaxel Will I feel better?
Your muscles or joints may ache or become painful two to three days after you have your treatment. This usually wears off after a few days to a week but may last a bit longer for some people. It can be very painful and you may need to take pain relief or anti-inflammatory drugs such as ibuprofen.