Does estrogen cause epiphyseal closure?
Estrogen hastens epiphyseal fusion and cessation of longitudinal bone growth.
How does estrogen affect epiphyseal plates?
First, estrogen reversibly suppresses growth plate function, including proliferation in the proliferative zone, hypertrophic cell size, and consequently the rate of longitudinal bone growth. Second, estrogen irreversibly advances structural senescence of the growth plate and hastens epiphyseal fusion.
Which hormone is responsible for epiphyseal fusion?
Estrogen is pivotal for epiphyseal fusion in both young men and women (10). This key role for estrogen was confirmed only recently with the recognition of two genetic disorders, estrogen deficiency due to mutations in the aromatase gene (11) and estrogen resistance due to mutations in the estrogen receptor-α gene (12).
How do you delay epiphyseal fusion?
It is suggested that treatment with aromatase inhibitors, alone or in combination with rh-GH, may also be useful in children with constitutional short stature in order to delay epiphyseal closure and improve the final height.
What is epiphyseal fusion?
It is the part of a long bone where new bone growth takes place; that is, the whole bone is alive, with maintenance remodeling throughout its existing bone tissue, but the growth plate is the place where the long bone grows longer (adds length). This replacement is known as epiphyseal closure or growth plate fusion.
How can I increase my bone growth plate?
Make sure that you eat a balanced diet, rich in calcium, magnesium and vitamin D. This gives your bones the materials it needs to grow. Do weight bearing exercises regularly. When you can, perform weight-bearing exercises such as walking or running.
Does estrogen cause growth plate fusion?
Estrogen is critical for epiphyseal fusion in both young men and women. In senescent growth plates, epiphyseal fusion was observed to be an abrupt event in which all remaining chondrocytes were rapidly replaced by bone elements.
How can I increase my epiphyseal growth plate?
Conclusions. Mechanical loading of the bone is important for epiphyseal plate physiology. Exercise has a healthy function on the normal growth of this important biomechanical feature. Clinically, over-exertion in the form of increased load bearing on the epiphyseal growth plate creates an ideal injury.
At what age do epiphyseal plates close?
Growth plates usually close near the end of puberty. For girls, this usually is when they’re 13–15; for boys, it’s when they’re 15–17.
When epiphyseal fusion occurs what happens?
This replacement is known as epiphyseal closure or growth plate fusion. Complete fusion can occur as early as 12 for girls (with the most common being 14-15 years for girls) and as early as 14 for boys (with the most common being 15–17 years for boys)….
Can you delay growth plate fusion?
Delaying and/or lengthening the period of epiphyseal fusion, with or without additional growth-promoting therapy, can result in an increase in adult height by allowing more time for growth-supporting treatments in short children, while promoting epiphyseal fusion may reduce adult height in extremely tall children.
How does estrogen trigger epiphyseal fusion?
Specifically, epiphyseal fusion seems to be triggered when the proliferative potential of the growth plate chondrocytes is finally exhausted. ( iii) Estrogen accelerates the growth plate senescence program, thereby exhausting the proliferative potential of growth plate chondrocytes sooner, consequently triggering earlier epiphyseal fusion.
In some mammals, including humans, the growth plate is resorbed at the time of sexual maturation. This process, epiphyseal fusion, terminates longitudinal bone growth. Estrogen is pivotal for epiphyseal fusion in both young men and women (10).
Does estrogen promote fusion in senescent growth plates?
Although our data suggest that estrogen promotes fusion indirectly by accelerating growth plate senescence, the findings do not exclude the possibility that, in senescent growth plates, estrogen is also required to complete the process of fusion. Estrogen also regulates human bone growth.
What is the pathophysiology of androgen activity in epiphyseal fusion?
In epiphyseal fusion, the activity of androgen is due to the aromatization of androgens to estrogens in various peripheral tissues, including growth plate cartilage36). Conclusions