Can pioglitazone cause fluid retention?
According to the manufacturers’ information, troglitazone, rosiglitazone, and pioglitazone may cause fluid retention in 2% to 5% of patients receiving monotherapy and 5% to 15% receiving concomitant insulin therapy 21, 22, 23.
Does Actos cause fluid retention?
ACTOS should be used with caution in patients with edema. Because thiazolidinediones, including ACTOS, can cause fluid retention, which can exacerbate or lead to congestive heart failure, ACTOS should be used with caution in patients at risk for congestive heart failure.
Is pioglitazone contraindicated in CHF?
Consider background risk, use low doses and monitor patients closely. Use of rosiglitazone or pioglitazone is contraindicated in patients with NYHA Class III and IV heart failure, and not recommended in patients with symptomatic heart failure.
What is the side effects of pioglitazone?
- Blurred vision or other changes in vision.
- flushed, dry skin.
- fruit-like breath odor.
- increased thirst.
- increased urination.
- muscle pain or soreness.
- problems with your teeth.
Does pioglitazone cause feet swelling?
Pioglitazone is associated with edema (peripheral, generalized, and pitting edema and fluid retention) when used alone or when used in combination therapy.
Does Actos cause ankle swelling?
Edema refers to swelling caused by a buildup of excess fluid in the body. This was a common side effect seen in clinical studies of Actos. Edema most commonly occurs in the hands and feet, particularly around the ankles.
Which best describes the mechanism of action of repaglinide?
Repaglinide lowers blood glucose levels by stimulating the release of insulin from the pancreas. This action is dependent upon functioning beta (ß) cells in the pancreatic islets. Insulin release is glucose-dependent and diminishes at low glucose concentrations.
How does pioglitazone contribute to heart failure?
Pioglitazone has been very popular as it is an insulin sensitizer and insulin resistance is prevalent among Indians. Fluid retention exacerbates pre-existing heart failure or precipitates heart failure in a patient with underlying left ventricular dysfunction.